A recent study has generated compelling experimental data on the role of GPR177 and WNT5a in the pathogenesis and treatment of painful diabetic neuropathy (PDN). The clinical value of these translational findings should be interpreted with caution. However, the limited efficacy of current treatments for PDN warrants further clinical studies on these novel pathways.
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R.M. has received honoraria for talks on painful neuropathy from Pfizer and Proctor and Gamble.
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Malik, R.A. Novel mechanisms of pain in painful diabetic neuropathy. Nat Rev Endocrinol 18, 459–460 (2022). https://doi.org/10.1038/s41574-022-00710-6
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DOI: https://doi.org/10.1038/s41574-022-00710-6
