Anti-interference characteristics, whereby undesirable signal interference is minimized, are required for multifunctional sensor platforms. In this study, an anti-temperature-interference resistive-type strain sensor, which does not respond to temperature but only to strain, is designed. Anti-interference properties were achieved by modulating the temperature coefficient of resistance (TCR) of metal nanoparticles (NPs) through hybrid chemical treatment with organic and halide ligands that induce negative and positive TCRs, respectively. Consequently, a very low TCR of 1.9 × 10⁻⁵ K⁻¹ was obtained. To investigate the origin of this near-zero TCR, analyses of correlated electrical, thermal, and mechanical properties were performed in addition to structural characterization and analysis. Density functional theory calculations and electrical percolation modeling were performed to illuminate the transport behavior in the near-zero-TCR NP thin films. Finally, we fabricated a high-performance anti-temperature-interference strain sensor using a solution process. The sensors detect a variety of strains, including those arising from large movements, such as wrist and knee movements, and fine movements, such as artery pulses or movements made during calligraphy, and did not respond to temperature changes.