Cell Stem Cell
Volume 29, Issue 6, 2 June 2022, Pages 882-904
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Review
Clonal hematopoiesis: Mutation-specific adaptation to environmental change

https://doi.org/10.1016/j.stem.2022.05.006Get rights and content
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Summary

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.

Keywords

clonal hematopoiesis
clonal competition
infection
inflammation
aging
chemotherapy
radiation
cancer

Cited by (0)

8

These authors contributed equally