Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry

Ying Yang; Linnan Li; Na Li; Fan Li; Wenxiang Fan; Yitian He; Zhengtao Wang; Li Yang

doi:10.1039/D2AN00565D

Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry†

Ying Yang,^a Linnan Li,

*^a Na Li,^a Fan Li,^a Wenxiang Fan,^a Yitian He,^a Zhengtao Wang*^ab and Li Yang

*^ab

Author affiliations

* Corresponding authors

^a The MOE Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
E-mail: linnanli@shutcm.edu.cn, yl7@shutcm.edu.cn, ztwang@shutcm.edu.cn

^b Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China

Abstract

Poria cocos, with medicinal and edible properties, contains multiple chemical components that pose difficulties in its quality control. Herein, we established a simple thin-layer chromatography spray ionization-mass spectrometry (TLCSI-MS) device that allows the simultaneous separation and identification of bioactive compounds. The triterpene acids in different medicinal parts of Poria cocos were characterized, and the markers of differences were revealed. The quantitative analysis of its pharmaceutical preparation has also been performed to verify the feasibility. The study provides a new analytical perspective for the screening and identification of multiple compounds and a good option for the quality evaluation of herbal medicines and foods.

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DOI: https://doi.org/10.1039/D2AN00565D
Article type: Paper
Submitted: 01 Apr 2022
Accepted: 17 May 2022
First published: 01 Jun 2022

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Analyst, 2022,147, 3072-3080

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Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry

Y. Yang, L. Li, N. Li, F. Li, W. Fan, Y. He, Z. Wang and L. Yang, Analyst, 2022, 147, 3072 DOI: 10.1039/D2AN00565D

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Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry†

Abstract

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Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry

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