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NEUROIMMUNOLOGY

CNS Treg cells have alternative functions but run on conventional fuel

Nature Immunology volume 23, pages 818–819 (2022)Cite this article

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Ectopic expression of IL-2 in the central nervous system (CNS) is sufficient to create an organ-restricted niche for tissue-resident regulatory T cells that support re-establishment of homeostasis after multiple types of tissue injury in the CNS.

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Fig. 1: IL-2 is a major controller of the Treg cell pool size.

References

  1. Pierson, W. et al. Nat. Immunol. 14, 959–965 (2013).

    Article  CAS  PubMed  Google Scholar 

  2. Arpaia, N. et al. Cell 162, 1078–1089 (2015).

    Article  CAS  PubMed  Google Scholar 

  3. Korn, T. & Muschaweckh, A. Front. Immunol. 10, 2634 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Yshii, L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01208-z (2022).

  5. Dombrowski, Y. et al. Nat. Neurosci. 20, 674–680 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Garg, G. et al. Cell Rep. 26, 1854–1868.E5 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Feuerer, M. et al. Nat. Med. 15, 930–939 (2009).

    Article  CAS  PubMed  Google Scholar 

  8. Vasanthakumar, A. et al. Nat. Immunol. 16, 276–285 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Vasanthakumar, A. et al. Cell Rep. 20, 2906–2920 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Delacher, M. et al. Immunity 52, 295–312.E11 (2020).

    Article  CAS  PubMed  Google Scholar 

  11. Sim, G. C. et al. J. Clin. Invest. 124, 99–110 (2014).

    Article  CAS  PubMed  Google Scholar 

  12. Huss, D. J. et al. J. Immunol. 194, 84–92 (2015).

    Article  CAS  PubMed  Google Scholar 

  13. Stork, L. et al. Mult. Scler. 25, 1618–1632 (2019).

    Article  CAS  PubMed  Google Scholar 

  14. Ronin, E. et al. Proc. Natl Acad. Sci. USA 118, e2014043118 (2021).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

T.K. is supported by the Deutsche Forschungsgemeinschaft (SFB1054-B06 (ID 210592381), TRR128-A07 (ID 213904703), TRR128-A12 (ID 213904703), TRR128-Z02 (ID 213904703), TRR274-A01 (ID 408885537), and EXC 2145 (SyNergy, ID 390857198)), the ERC (CoG 647215), and by the Hertie Network of Clinical Neuroscience.

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  1. Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine, Munich, Germany

    Thomas Korn

  2. Department of Neurology, Technical University of Munich School of Medicine, Munich, Germany

    Thomas Korn

  3. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Thomas Korn

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  1. Thomas Korn
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Correspondence to Thomas Korn.

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Korn, T. CNS Treg cells have alternative functions but run on conventional fuel. Nat Immunol 23, 818–819 (2022). https://doi.org/10.1038/s41590-022-01201-6

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