Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER IMMUNOTHERAPY

Lipid nanodiscs give cancer a STING

Nature Materials volume 21, pages 616–617 (2022)Cite this article

Subjects

Lipid nanodiscs carrying a potent STING agonist penetrate deep into solid tumours compared with gold-standard liposomes and enable long-term antitumour immunotherapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Lipid nanodiscs give cancer immunotherapy a STING.

References

  1. Yang, Y. J. Clin. Invest. 125, 3335–3337 (2015).

    Article  Google Scholar 

  2. Hopfner, K.-P. & Hornung, V. Nat. Rev. Mol. Cell Biol. 21, 501–521 (2020).

    Article  CAS  Google Scholar 

  3. Deng, L. et al. Immunity 41, 843–852 (2014).

    Article  CAS  Google Scholar 

  4. Dane, E. L. et al. Nat. Mater. https://doi.org/10.1038/s41563-022-01251-z (2022).

    Article  Google Scholar 

  5. Harper, S., Usenko, C., Hutchison, J., Maddux, B. & Tanguay, R. J. Exp. Nanosci. 3, 195–206 (2008).

    Article  CAS  Google Scholar 

  6. Kuai, R., Ochyl, L. J., Bahjat, K. S., Schwendeman, A. & Moon, J. J. Nat. Mater. 16, 489–496 (2017).

    Article  CAS  Google Scholar 

  7. Li, S. et al. Nat. Biomed. Eng. 5, 455–466 (2021).

    Article  CAS  Google Scholar 

  8. Wang, F. et al. Nat. Biomed. Eng. 4, 1090–1101 (2020).

    Article  CAS  Google Scholar 

  9. Shae, D. et al. Nat. Nanotechnol. 14, 269–278 (2019).

    Article  CAS  Google Scholar 

  10. Liu, S. & Jiang, S. Nano Today 11, 285–291 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

    Ningqiang Gong & Michael J. Mitchell

Authors
  1. Ningqiang Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael J. Mitchell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael J. Mitchell.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gong, N., Mitchell, M.J. Lipid nanodiscs give cancer a STING. Nat. Mater. 21, 616–617 (2022). https://doi.org/10.1038/s41563-022-01270-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41563-022-01270-w

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research