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CANCER EPIGENETICS

Putting introns on retainer

Nature Chemical Biology volume 18, pages 795–796 (2022)Cite this article

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Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.

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Fig. 1: Antitumoral immune response triggered by retained introns.

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Authors and Affiliations

  1. Segal Cancer Centre, Lady Davis Institute, Montreal, Quebec, Canada

    Nivine Srour & Stéphane Richard

  2. Gerald Bronfman Department of Oncology, McGill University, Montréal, Quebec, Canada

    Nivine Srour & Stéphane Richard

  3. Department of Biochemistry, McGill University, Montréal, Quebec, Canada

    Nivine Srour & Stéphane Richard

  4. Department of Human Genetics, McGill University, Montréal, Quebec, Canada

    Nivine Srour & Stéphane Richard

  5. Department of Medicine, McGill University, Montréal, Quebec, Canada

    Nivine Srour & Stéphane Richard

Authors
  1. Nivine Srour
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  2. Stéphane Richard
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Correspondence to Stéphane Richard.

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The authors declare no competing interests.

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Srour, N., Richard, S. Putting introns on retainer. Nat Chem Biol 18, 795–796 (2022). https://doi.org/10.1038/s41589-022-01025-3

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