Elsevier

Matrix Biology

Volume 114, December 2022, Pages 138-155
Matrix Biology

The dynamic kidney matrisome - is the circadian clock in control?

https://doi.org/10.1016/j.matbio.2022.05.005Get rights and content
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Highlights

  • Extracellular matrix-rich tissues, including the kidney, display functional circadian rhythms.

  • Dysfunction of core clock components has been implicated in the pathogenesis of diseases characterised by abnormal ECM.

  • ECM properties regulate circadian clocks in a tissue-specific manner.

  • This review focuses on the interface of matrix biology and circadian biology in the context of kidney physiology and disease.

  • Deciphering the temporal regulation of extracellular matrices may uncover novel therapeutic pathways in regulating the ageing and diseased ECM.

Abstract

The circadian clock network in mammals is responsible for the temporal coordination of numerous physiological processes that are necessary for homeostasis. Peripheral tissues demonstrate circadian rhythmicity and dysfunction of core clock components has been implicated in the pathogenesis of diseases that are characterized by abnormal extracellular matrix, such as fibrosis (too much disorganized matrix) and tissue breakdown (too little matrix). Kidney disease is characterized by proteinuria, which along with the rate of filtration, displays robust circadian oscillation. Clinical observation and mouse studies suggest the presence of 24 h kidney clocks responsible for circadian oscillation in kidney function. Recent experimental evidence has also revealed that cell-matrix interactions and the biomechanical properties of extracellular matrix have key roles in regulating peripheral circadian clocks and this mechanism appears to be cell- and tissue-type specific. Thus, establishing a temporally resolved kidney matrisome may provide a useful tool for studying the two-way interactions between the extracellular matrix and the intracellular time-keeping mechanisms in this critical niche tissue. This review summarizes the latest genetic and biochemical evidence linking kidney physiology and disease to the circadian system with a particular focus on the extracellular matrix. We also review the experimental approaches and methodologies required to dissect the roles of circadian pathways in specific tissues and outline the translational aspects of circadian biology, including how circadian medicine could be used for the treatment of kidney disease.

Keywords

Circadian clock
Kidney
Glomerulus
Extracellular matrix
Basement membrane

Abbreviation

ECM
extracellular matrix
BM
basement membrane
GBM
glomerular basement membrane
CKD
chronic kidney disease
BP
blood pressure

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