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A Sequential Stimulus-Responsive Nanoparticle Platform for Enhanced Tumor Growth Inhibition and Efficient Drug Delivery

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Abstract

Purpose

In this study, we fabricated a nanoplatform to target tumor sites via active and passive targeting effects, thus avoiding the toxic side effects of nanocarriers and improving the efficacy of chemotherapeutic drug delivery.

Methods

A sequential stimulus-responsive nanoparticle that targeted the tumor microenvironment and exhibited dual sensitivity to the reduction condition and matrix metalloproteinase-9 (MMP-9) enzyme was fabricated based on a self-assembled polypeptide-paclitaxel conjugate.

Results

The nanoparticles (48.9 ± 2.1 nm) transformed into rod-like nanostructures (297.1 ± 3.2 nm) in the presence of MMP-9. The rod-like nanostructures were taken up by tumor cells and then sensitive bonds were broken in response to highly expressed GSH in tumor cells to release drugs. This platform showed a tumor inhibition rate of 71.8% in S180-bearing mice and a more effective tumor inhibition rate than Taxol in 4T1-bearing mice.

Conclusion

This platform facilitates the design of enhanced safe and efficient chemotherapy drug delivery.

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Data Availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Funding

This work was supported by the Natural Science Foundation of Ningbo (2019A610299).

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All authors contributed to the study conception and design. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yu Sun.

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Cite this article

Sun, Y. A Sequential Stimulus-Responsive Nanoparticle Platform for Enhanced Tumor Growth Inhibition and Efficient Drug Delivery. J Pharm Innov 18, 426–436 (2023). https://doi.org/10.1007/s12247-022-09653-x

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  • DOI: https://doi.org/10.1007/s12247-022-09653-x

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