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Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia

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References

  1. Buciuc M, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Boeve BF et al (2020) Association between transactive response DNA-binding protein of 43 kDa type and cognitive resilience to Alzheimer’s disease: a case-control study. Neurobiol Aging 92:92–97. https://doi.org/10.1016/j.neurobiolaging.2020.04.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Josephs KA, Murray ME, Whitwell JL, Tosakulwong N, Weigand SD, Petrucelli L et al (2016) Updated TDP-43 in Alzheimer’s disease staging scheme. Acta Neuropathol 131:571–585. https://doi.org/10.1007/s00401-016-1537-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Josephs KA, Murray ME, Tosakulwong N, Weigand SD, Serie AM, Perkerson RB et al (2019) Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains. Acta Neuropathol 137:227–238. https://doi.org/10.1007/s00401-018-1951-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA et al (2013) TDP-43 pathology, cognitive decline, and dementia in old age. JAMA Neurol 70:1418–1424. https://doi.org/10.1001/jamaneurol.2013.3961

    Article  PubMed  Google Scholar 

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Funding

This research was supported by Foundation for the National Institutes of Health (Grants R01 AG037491, P30 AG062677, U01 AG006786).

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Authors and Affiliations

  1. Department of Neurology, Mayo Clinic, 200 1st St S.W., Rochester, MN, 55905, USA

    Arenn F. Carlos, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen & Keith A. Josephs

  2. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

    Nirubol Tosakulwong & Stephen D. Weigand

  3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Aivi Nguyen & R. Ross Reichard

  4. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Melissa E. Murray & Dennis W. Dickson

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  1. Arenn F. Carlos
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  2. Nirubol Tosakulwong
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  3. Stephen D. Weigand
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  4. Bradley F. Boeve
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  5. David S. Knopman
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  7. Aivi Nguyen
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  9. Melissa E. Murray
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  11. Keith A. Josephs
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Correspondence to Keith A. Josephs.

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Carlos, A.F., Tosakulwong, N., Weigand, S.D. et al. Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia. Acta Neuropathol 144, 159–160 (2022). https://doi.org/10.1007/s00401-022-02434-3

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  • DOI: https://doi.org/10.1007/s00401-022-02434-3

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