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Diagnosis and Management of Microscopic Colitis in Pediatric Patients

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Abstract

Microscopic colitis (MC) is an inflammatory disease of the colon, characterized by chronic watery diarrhea with distinguishing histologic findings despite normal endoscopic appearance of the colonic mucosa. MC is a common cause of diarrhea in older adults, though it has been infrequently reported in children and adolescents. As MC is rare in the pediatric population, and the clinical presentation is non-specific, increased awareness of this disease amongst pediatric clinicians and pathologists is essential for timely diagnosis, which requires performing colonoscopy with biopsy. The etiology of MC is incompletely understood, but current theories in pathogenesis inform management strategies. The goals of management in pediatric MC should be to achieve symptomatic improvement while minimizing adverse effects of treatment. Many patients who achieve clinical response have symptomatic recurrence after discontinuation of initial therapy, and may require maintenance medication therapy to sustain remission. This review aims to summarize the epidemiology and risk factors, clinical features, diagnosis, theories regarding pathogenesis, and suggested management approaches for MC in the pediatric population.

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Acknowledgements

We thank Lysandra Voltaggio, MD of the Department of Pathology and Laboratory Medicine at the Johns Hopkins Hospital for providing the histological images for Figs. 1 and 2.

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    Salina Khushal & Maria Oliva-Hemker

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Khushal, S., Oliva-Hemker, M. Diagnosis and Management of Microscopic Colitis in Pediatric Patients. Pediatr Drugs 24, 217–233 (2022). https://doi.org/10.1007/s40272-022-00504-3

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