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NEUROSCIENCE

Astroglial clean-up of satiety synapses

Nature Metabolism volume 4, pages 505–506 (2022)Cite this article

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Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

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Fig. 1: Astrocytes govern excitatory neurotransmission and feeding behaviour by integrating BDNF–TrkB.T1 signalling.

References

  1. Brobeck, J. R. Physiol. Rev. 26, 541–559 (1946).

    Article  CAS  Google Scholar 

  2. Nedergaard, M. & Verkhratsky, A. Glia 60, 1013–1023 (2012).

    Article  Google Scholar 

  3. Rios, M. et al. Mol. Endocrinol. 15, 1748–1757 (2001).

    Article  CAS  Google Scholar 

  4. Xu, B. et al. Nat. Neurosci. 6, 736–742 (2003).

    Article  CAS  Google Scholar 

  5. Unger, T. J., Calderon, G. A., Bradley, L. C., Sena-Esteves, M. & Rios, M. J. Neurosci. 27, 14265–14274 (2007).

    Article  CAS  Google Scholar 

  6. Liao, G. Y. et al. Nat. Med. 18, 564–571 (2012).

    Article  CAS  Google Scholar 

  7. Ameroso, D., Meng, A., Felsted, J., Dulla, C. G. & Rios, M. Nat. Metab. https://doi.org/10.1038/s42255-022-00566-0 (2022).

  8. Murat, C. B. & García-Cáceres, C. Metabolites 11, 732 (2021).

    Article  CAS  Google Scholar 

  9. Licht, T. & Keshet, E. Cell. Mol. Life Sci. 70, 1727–1737 (2013).

    Article  CAS  Google Scholar 

  10. Gruber, T. et al. Cell Metab. 33, 1155–1170.e10 (2021).

  11. Noriega-Prieto, J. A. et al. J. Neurosci. 41, 4768–4781 (2021).

Download references

Acknowledgements

The authors thank C. Holleman for her comments. The authors’ research is supported by funding from the European Research Council ERC (CGC: STG grant AstroNeuroCrosstalk # 757393), the German Research Foundation DFG under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198) and Helmholtz Excellence Network and the Deutsche Forschungsgemeinschaft (GS: SPP1757 - SA2114/2-2), and Helmholtz Association – Initiative and Networking Fund. The funders had no role in the decision to publish or prepare this work.

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Authors and Affiliations

  1. Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München & German Center for Diabetes Research (DZD), Neuherberg, Germany

    Tim Gruber & Cristina García-Cáceres

  2. Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany

    Cristina García-Cáceres

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  1. Tim Gruber
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  2. Cristina García-Cáceres
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Correspondence to Cristina García-Cáceres.

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Gruber, T., García-Cáceres, C. Astroglial clean-up of satiety synapses. Nat Metab 4, 505–506 (2022). https://doi.org/10.1038/s42255-022-00563-3

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