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Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape

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Abstract

Three new pentacyclic triterpenes, trivially named sandkoetjapic acids A–C (1–3), have been isolated from the leaves extract of Sandoricum koetjape, along with the known triterpenes 3-oxo-olean-12-en-29-oic (4), bryonolic (5), and bryononic (6) acids. The structures of the new triterpenes were determined mainly by NMR spectroscopic and mass spectroscopic data. The isolation of these pentacyclic triterpenes in the plant’s leaves is for the first time. Preliminary biological evaluation of 1–6 was done against eight receptor tyrosine kinases (RTKs), including EGFR, HER2, HER4 (epidermal growth factor receptor), IGF1R, InsR (insulin receptor), KDR (kinase insert domain receptor), and PDGFRα/-β (platelet-derived growth factor receptor), and their inhibitory properties against β-lactamase. The results showed that none of them were active both as the inhibitors of these RTKs and β-lactamase.

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Acknowledgements

We acknowledge the Grant of Higher Education Excellent Basic Science (PDUPT) Scheme (Contract Number 120F/IT1.C02/TA.00/2021), The Higher Education Bureau, The Ministry of Education and Culture of Indonesia, for financial support to this research.

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Authors and Affiliations

  1. Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia

    Karlina Saptanti, Elvira Hermawati & Yana M. Syah

  2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor, Indonesia

    Leny Heliawati

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  1. Karlina Saptanti
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  2. Leny Heliawati
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  3. Elvira Hermawati
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  4. Yana M. Syah
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Correspondence to Yana M. Syah.

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Saptanti, K., Heliawati, L., Hermawati, E. et al. Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape. J Nat Med 76, 842–848 (2022). https://doi.org/10.1007/s11418-022-01620-7

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