The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
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Yang, ZH., Han, J. Dual ligand engagement for noncanonical inflammasome activation. Nat Immunol 23, 651–653 (2022). https://doi.org/10.1038/s41590-022-01188-0
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DOI: https://doi.org/10.1038/s41590-022-01188-0
