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MASS SPECTROMETRY

Seeing flying molecular elephants more clearly

Nature Chemistry volume 14, pages 482–483 (2022)Cite this article

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Extending mass spectrometry measurements of biomolecules into the megadalton regime is challenging due to the limited resolving power of currently used mass analysers. Now, using single ion-charge detection Orbitrap mass spectrometry, a mass accuracy of 0.001% has been demonstrated for protein particles larger than 9 MDa.

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Fig. 1: Orbitrap-based CDMS.

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Authors and Affiliations

  1. Australian Proteome Analysis Facility, Macquarie University, New South Wales, Australia

    Muhammad A. Zenaidee

  2. Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, University of California-Los Angeles, Los Angeles, CA, USA

    Joseph A. Loo

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  1. Muhammad A. Zenaidee
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  2. Joseph A. Loo
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Correspondence to Muhammad A. Zenaidee or Joseph A. Loo.

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The authors declare no competing interests.

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Zenaidee, M.A., Loo, J.A. Seeing flying molecular elephants more clearly. Nat. Chem. 14, 482–483 (2022). https://doi.org/10.1038/s41557-022-00941-0

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