Abstract
Purpose
The occurrence of adverse events (AE) in hospitalized patients substancially increases the risk of disability or death, having a major negative clinical and economic impact on public health. For early identification of patients at risk and to establish preventive measures, different healthcare systems have implemented rapid response systems (RRS). The aim of this study was to carry out a cost-effectiveness analysis of implementing a RRS in a tertiary-care hospital.
Methods
We included all the patients admitted to Hospital Clínic de Barcelona from 1 to 2016 to 31 December 2016. The cost-effectiveness analysis was summarized as the incremental cost-effectiveness ratio (incremental cost divided by the incremental effectiveness of the two alternatives, RRS versus non-RRS). The effectiveness of the RRS, defined as improvements in health outcomes (AE, cardiopulmonary arrest and mortality), was obtained from the literature and applied to the included patient cohort. A budget impact analysis on the implementation of the RRS from a hospital perspective was performed over a 5-year time horizon.
Results
42,409 patients were included, and 448 (1.05%) had severe AE requiring ICU admission. The cost-effectiveness analysis showed an incremental cost (savings) of EUR − 1,471,101 of RRS versus the non-RRS. The budgetary impact showed a cost reduction of EUR 896,762.00 in the first year and EUR 1,588,579.00 from the second to the fifth year.
Conclusions
The present analysis shows the RRS as a dominant, less costly and more effective structure compared to the non-RRS.
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References
Vlayen A, Verelst S, Bekkering G, Schoorooten W, Hellings J, Claes N. Incidence and preventability of adverse events requiring intensive care admission: a systematic review. J Eval Clin Pract 2012; 18:485 – 97. https://doi.org/10.1111/j.1365-2753.2010.01612.x.
Buist MD, Jarmolowski E, Burton PR, Bernard SA, Waxman BP, Anderson J. Recognising clinical instability in hospital patients before cardiac arrest or unplanned admission to intensive care. A pilot study in a tertiary-care hospital. Med J Aust 1999; 171:404–409. https://doi.org/10.5694/j.1326-5377.1999.tb123492.x.
Darchy B, Le Miere E, Figueredo B, Bavoux E, Domart Y. Iatrogenic diseases as a reason for admission to the intensive care unit: incidence, causes and consequences. Arch Intern Med. 1999;159:71–8. doi:https://doi.org/10.1001/archinte.159.1.71.
Kurowski I, Sims C. Unplanned anesthesia-related admissions to pediatric intensive care – a 6-year audit. Paediatr Anaesth 2007; 17:575–580. https://doi.org/10.1111/j.1460-9592.2006.02154.x
Swann D, Houston P, Goldberg J. Audit of intensive care unit admissions from the operating room. Can J Anaesth. 1993;40:137–41. https://doi.org/10.1007/BF03011311.
Al-Qahtani S, Al-Dorzi HM, Tamim HM, Hussain S, Fong L, Taher S, et al. Impact of an intensivist led multidisciplinary extended rapid response team on hospital-wide cardiopulmonary arrests and mortality. Crit Care Med. 2013;41:506–17. https://doi.org/10.1097/ccm.0b013e318271440b.
Ludikhuize J, Brunsveld-Reinders AH, Dijkgraaf MG, Smorenburg SM, de Rooij SE, Adams R, et al. Outcomes associated with the nationwide introduction of rapid response systems in the Netherlands. Crit Care Med. 2015;43:2544–51. https://doi.org/10.1097/ccm.0000000000001272.
De Jong A, Jung B, Daurat A, Chanques G, Mahul M, Monnin M, et al. Effect of rapid response systems on hospital mortality: A systematic review and meta-analysis. Int Care Med. 2016;42:615–7. https://doi.org/10.1007/s00134-016-4263-1.
McGaughey J, Alderdice F, Fowler R, Kapila A, Mayhew A, Mouttray M. Outreach and Early Warning Systems (EWS) for the prevention of intensive care admission and death of critically ill adult patients on general hospital wards. Cochrane Database Syst Rev 2007;(3): CD005529. https://doi.org/10.1002/14651858.cd005529.pub2.
Chen J, Ou L, Flabouris A, Hillman K, Bellomo R, Parr M. Impact of a standardized rapid response system on outcomes in a large healthcare jurisdiction. Resuscitation. 2016;107:47–56. https://doi.org/10.1016/j.resuscitation.2016.07.240.
Jung B, Daurat A, De JA, Chanques G, Mahul M, Monnin M, et al. Rapid response team and hospital mortality in hospitalized patients. Int Care Med. 2016;42:494–504. https://doi.org/10.1007/s00134-016-4254-2.
Escobar G, Liu V, Schuler A, Lawson B, Greene J, Kipnis P. Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration. N Engl J Med. 2020;383:1951–60. https://doi.org/10.1056/nejmc2034836.
Subbe C, Bannard-Smith J, Bunch J, Champunot R, DeVita M, Durham L, et al. On behalf of the International Society of Rapid response Systems. Quality metrics for the evaluation of Rapid Response System: Proceedings from the third international consensus conference on Rapid Response Systems. Resuscitation 2019; 141:1–12. https://doi.org/10.1016/j.resuscitation.2019.05.012.
Spaulding A, Ohsfeldt R. Rapid response teams and team composition: a cost-effectiveness analysis. Nurs Econ. 2014;32:194–203.
Murphy A, Cronin J, Whelan R, Drummond FJ, Savage E, Hegarty J. Economics of Early Warning Scores for identifying clinical deterioration – a systematic review. Ir J Med Sci. 2017. DOI:https://doi.org/10.1007/s11845-017-1631-y.
Simmes F, Schoonhoven L, Mintjes J, Adang E, van der Hoeven J. Financial consequences of the implementation of a rapid response system on a surgical ward. J Eval Clin Pract 2014; 20:342–347. https://doi.org/10.1111/jep.12134.
Alam N, Hobbelink EL, van Tienhoven AJ, van de Ven PM, Jansma EP, Nanayakkara PWB. The impact of the use of the Early Warning Score (EWS) on patient outcomes: A systematic review. Resuscitation. 2015;85:587–94. https://doi.org/10.1016/j.resuscitation.2014.01.013.
https://www.ine.es/jaxiT3/Tabla.htm?t=1414. Last access: 04/12/2021.
Shorr A, Micek S, Jackson W, Kolleef M. Economic implications of an evidence-based sepsis protocol: Can we improve outcomes and lower costs? Crit Care Med. 2007;35:1257–62. doi:https://doi.org/10.1097/01.CCM.0000261886.65063.CC.
Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes. Oxford university press; 2015.
DeVita M, Hillman K, Bellomo R. Textboof of Rapid Response Systems. Concept and Implementation. (2017), Second edition. Springer Nature. DOI: https://doi.org/10.1007/978-3-319-39391-9.
Winters B, Weaver S, Pfoh E, et al. Rapid-Response Systems as a Patient Safety Strategy. A Systematic Review. Ann Intern Med. 2013;158:417–25. DOI:https://doi.org/10.7326/0003-4819-158-5-201303051-00009.
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All authors contributed to the study design and concepcion. Data collection were perfomed by David Esteve, Borja García-Lorenzo, Guido Muñoz, Susagna Trias and Ricard Mellado. Data analysis performed by Borja García-Lorenzo and Susagna Trias. The first draft was written by Guido Muñoz, Borja García-Lorenzo and Carlos Ferrando, and all authors commented on previous version of the manuscript.
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The study was approved by the Clinical Research Ethics Committee of Hospital Clínic de Barcelona (HCB/2017/0862).
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Muñoz-Rojas, G., García-Lorenzo, B., Esteve, D. et al. Implementing a Rapid Response System in a tertiary-care hospital. A cost-effectiveness study. J Clin Monit Comput 36, 1263–1269 (2022). https://doi.org/10.1007/s10877-022-00859-5
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DOI: https://doi.org/10.1007/s10877-022-00859-5