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PROTEIN AGGREGATION

Centrosomes grow aggresomes to clear waste

Nature Cell Biology volume 24, pages 408–410 (2022)Cite this article

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Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

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Fig. 1: Models for CP110 and centriolar satellite function in aggresome assembly and in pathological protein aggregation.

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Authors and Affiliations

  1. Department of Biochemistry, University of Oxford, Oxford, UK

    Elisa Vitiello & Fanni Gergely

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  1. Elisa Vitiello
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  2. Fanni Gergely
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Correspondence to Fanni Gergely.

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The authors declare no competing interests.

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Vitiello, E., Gergely, F. Centrosomes grow aggresomes to clear waste. Nat Cell Biol 24, 408–410 (2022). https://doi.org/10.1038/s41556-022-00891-2

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