Microproteins can be generated by a shift in the reading frame during translation. A chemoproteomics approach led to the identification of MINAS-60 as an alternative microprotein that regulates the assembly of the pre-60S ribosome.
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References
Saghatelian, A. & Couso, J. P. Nat. Chem. Biol. 11, 909–916 (2015).
D'Lima, N. G. et al. Nat. Chem. Biol. 13, 174–180 (2017).
Ray, S. et al. Elife https://doi.org/10.7554/eLife.39748 (2019).
Graeff, M. et al. PLoS Genet. 12, e1005959 (2016).
Hong, S. Y. et al. Proc. Natl Acad. Sci. USA 117, 26197–26205 (2020).
Cao, W. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01003-9 (2022).
Makarewich, C. A. et al. Proc. Natl Acad. Sci. USA 119, e2120476119 (2022).
Rodrigues, V. L. et al. Plant Physiol. 187, 187–202 (2021).
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Kruusvee, V., Wenkel, S. Microproteins — lost in translation. Nat Chem Biol 18, 581–582 (2022). https://doi.org/10.1038/s41589-022-01007-5
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DOI: https://doi.org/10.1038/s41589-022-01007-5