Chemoproteomics reveals a cysteine oxidation event that inhibits the maturation process of a lysosomal protease, enabling its secretion into the extracellular space during infection-induced tumorigenesis. A recent study offers a new mechanistic paradigm for redox-dependent regulation of protein trafficking.
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Yang, J. Oxidize me to the space. Nat Chem Biol 18, 680–681 (2022). https://doi.org/10.1038/s41589-022-00986-9
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DOI: https://doi.org/10.1038/s41589-022-00986-9
