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NEURODEGENERATIVE DISEASE

Transcriptomic mapping of the human cerebrovasculature

Nature Reviews Neurology volume 18, pages 319–320 (2022)Cite this article

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The mechanistic contribution of cerebrovascular dysfunction to neurodegenerative diseases is difficult to determine. New single-cell transcriptomic analyses of human brain microvessels have identified transcriptomic signatures along the arteriovenous axis and transcriptional changes in the cerebrovasculature in Alzheimer disease and Huntington disease. This approach could advance our understanding of brain health and disease.

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Fig. 1: Human cerebrovascular cell subtypes.

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Authors and Affiliations

  1. Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan

    Masafumi Ihara

  2. Department of Molecular Innovation in Lipidemiology, National Cerebral and Cardiovascular Center, Suita, Japan

    Yumi Yamamoto

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  1. Masafumi Ihara
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  2. Yumi Yamamoto
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Correspondence to Masafumi Ihara.

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The authors declare no competing interests.

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Ihara, M., Yamamoto, Y. Transcriptomic mapping of the human cerebrovasculature. Nat Rev Neurol 18, 319–320 (2022). https://doi.org/10.1038/s41582-022-00650-9

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