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Development and Characterization of Viburnum opulus L. Extract-Loaded Orodispersible Films: Potential Route of Administration for Phytochemicals

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Abstract

Purpose

Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems, hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films (ODFs) to enhance oral absorption and improve patient compliance.

Methods

ODF formulations were prepared using the solvent casting method. Carboxymethyl cellulose (0.5%, 1%, 1.5% w/w) and chitosan (0.5%, 1%, 1.5% w/w) were selected as film-forming polymers and glycerol was utilized as a plasticizer. Chlorogenic acid is the major metabolite of V. opulus fruits. The chlorogenic acid content in formulations and the plant extract was measured using high-performance thin-layer chromatography (HPTLC). Characterization studies on the formulations such as elongation at break, tensile strength, Young’s modulus, DSC, SEM, and FT-IR were conducted. Bioadhesion, in vitro disintegration, and in vitro release studies were performed.

Results

Desired mechanical and morphological properties were obtained for ODFs. Disintegration times (15.38 ± 0.88 s) and release studies (85.19% at 30 min) showed that the 0.5% chitosan films were the most convenient formulation for delivering V. opulus extract.

Conclusion

ODFs were evaluated as a smart delivery route for phytochemicals avoiding any gastrointestinal effects and enhancing oral absorption.

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Acknowledgements

The authors would like to thank Prof. Dr. Serap Arbak for providing the electron microscopy laboratories and also would like to thank Selcuk Birdogan (Ph.D.) for obtaining the SEM images.

Funding

No funding was received for performing this study.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Acibadem University, Istanbul, Turkey

    Samet Özdemir, Egemen Çakırlı & Bilge Sürücü

  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul Health and Technology University, Istanbul, Turkey

    Samet Özdemir

  3. Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara Medipol University, Ankara, Turkey

    Alptuğ Karaküçük

  4. Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey

    Alptuğ Karaküçük

  5. Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey

    Burcu Üner

  6. Department of Pharmacognosy, Faculty of Pharmacy, Acibadem University, Istanbul, Turkey

    Timur Hakan Barak & Hilal Bardakçı

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  1. Samet Özdemir
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Özdemir, S., Karaküçük, A., Çakırlı, E. et al. Development and Characterization of Viburnum opulus L. Extract-Loaded Orodispersible Films: Potential Route of Administration for Phytochemicals. J Pharm Innov 18, 90–101 (2023). https://doi.org/10.1007/s12247-022-09627-z

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