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Nanonization-Based Solubility Enhancement by Loaded Porous Starch Foam: Nifedipine Tablet Formulation

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Abstract

Background

Nifedipine (NIF) is a 1,4-dihydropyridine, calcium channel blocker, widely used in the treatment of cardiovascular diseases. NIF is poorly soluble in water at room temperature. Biodegradable porous starch foam (BPSF) has great potential as a solid dispersion carrier and can improve the solubility of poorly water-soluble drugs like NIF.

Objective

To formulate and evaluate tablet formulation of nifedipine-loaded biodegradable porous starch foam to improve the solubility of the drug.

Methods

The physical properties and the dissolution profile of NIF/BPSF mixtures and tablets were investigated. The BPSF was prepared by using a solvent exchange method, and NIF was loaded using an immersion/solvent evaporation method. The samples were characterized using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), and optical microscopy.

Results

The in vitro dissolution studies demonstrated the immediate release of NIF from the BPSF formulated tablets. The formulation containing a ratio of NIF:BPSF (1:10) gave around 70% drug release in 30 min as compared to the control NIF tablets that showed 11% drug release.

Conclusion

These results showed an increase in the drug release of NIF from BPSF as a carrier thereby supporting the mechanism of drug adsorption.

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Acknowledgements

The authors would like to thank Mr. Sujay Gurav for providing help during the studies.

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Authors and Affiliations

  1. Campbell University College of Pharmacy and Health Sciences, PO Box 1090, Buies Creek, NC, 27506, USA

    Pratibha Milind Chaudhari, Paul Johnson & Antoine Al-Achi

  2. Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra, 412105, India

    Raksha Laxman Mhetre

Authors
  1. Pratibha Milind Chaudhari
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  2. Paul Johnson
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  3. Raksha Laxman Mhetre
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  4. Antoine Al-Achi
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Correspondence to Antoine Al-Achi.

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Chaudhari, P.M., Johnson, P., Mhetre, R.L. et al. Nanonization-Based Solubility Enhancement by Loaded Porous Starch Foam: Nifedipine Tablet Formulation. J Pharm Innov 18, 60–67 (2023). https://doi.org/10.1007/s12247-022-09622-4

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  • DOI: https://doi.org/10.1007/s12247-022-09622-4

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