Original articlePuerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway
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Graphical abstract
Keywords
Puerarin
F-actin ring
Integrin-β3
Pyk2/Cbl/Src
Osteoclast activation
Abbreviations
Atp6v0d2
ATPase H + Transporting V0 Subunit D2
BMD
Bone mineral density
BS
Bone surface
OVX
ovariectomized
BMMs
Bone marrow monocyte cells
BV/TV
Bone volume/tissue volume
c-Fos: Proto-oncogene C-Fos
Ct. Ar
Cortical area
CTx1
carboxyl-terminal telopeptides of type I collagen
CLCN7
Charge-coupled Cl-channel
CA II
Carbonic anhydrase II
Cs. Th
Cortical thickness
Conn. D
Connectivity density
CTSK
Cathepsin K
E2: 17-β estradiol
Ec. Pm
Endocortical perimeter
ER
Estrogen receptor
M-CSF
Macrophage colony-stimulating factor
Src: Proto-oncogene tyrosine-protein kinase Src
Ma. Ar
Marrow area
MRM
Multiple reaction monitoring
MMP9
Matrix metalloproteinase-9
N. Oc
Number of trap positive osteoclasts
NFATc1
Nuclear factor of activated T cells 1
TRAP-5b
Tartrate-resistant acid phosphatase 5b
OC-STAMP
Osteoclast stimulatory transmembrane protein
OPG
Osteoprotegerin
Oc. S
Osteoclasts surface
P1NP
Amino-terminal propeptide of type I collagen
RANKL
Receptor activator of nuclear factor κ-B ligand
RLU
Luminescence
SD
Sprague–Dawley
rBMSC
rat bone marrow-derived mesenchymal stem cells. Tb. N
Trabecular number
Tb. Th
Trabecular thickness
Tb. Sp
Trabecular separation
TRAP
Tartrate resistant acid phosphatase
TRAF6
TNF-receptor-associated factor 6
TUNEL
Terminal deoxynucleotidyl transferase dUTP nick end labeling
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The authors contribute equally to this paper.
© 2022 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.