References
Deschepper M, Waegeman W, Eeckloo K et al (2018) Effects of chlorhexidine gluconate oral care on hospital mortality: a hospital-wide, observational cohort study. Intensive Care Med 44:1017–1026. https://doi.org/10.1007/s00134-018-5171-3
Dale CM, Rose L, Carbone S et al (2021) Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med 47:1295–1302. https://doi.org/10.1007/s00134-021-06475-2
Blot S (2021) Antiseptic mouthwash, the nitrate-nitrite-nitric oxide pathway, and hospital mortality: a hypothesis generating review. Intensive Care Med 47:28–38. https://doi.org/10.1007/s00134-020-06276-z
Dougall HT, Smith L, Duncan C, Benjamin N (1995) The effect of amoxycillin on salivary nitrite concentrations: an important mechanism of adverse reactions? Br J Clin Pharmacol 39:460–462. https://doi.org/10.1111/j.1365-2125.1995.tb04479.x
Montenegro MF, Sundqvist ML, Larsen FJ et al (2017) Blood pressure-lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor. Hypertension 69:23–31. https://doi.org/10.1161/HYPERTENSIONAHA.116.08081
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
None of the authors has a conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Blot, S., Deschepper, M. & Labeau, S. De-adoption of chlorhexidine oral care and ICU mortality. Intensive Care Med 48, 624–625 (2022). https://doi.org/10.1007/s00134-022-06621-4
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00134-022-06621-4