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Genetic variation and association mapping of phenolic, flavonoid content and antioxidant capacity in USDA rice mini-core collection

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Abstract

Genotypic diversity of total phenolics, flavonoid content and antioxidant capacity in the USDA rice mini-core collection was analyzed. Wide genotypic variation was found in total phenolics, flavonoid content and ABTS antioxidant capacity. Genome-wide association mapping between the three antioxidant traits and 155 SSR markers was conducted using Q + K model which takes both population structure (Q) and relative kinship (K) into consideration. A total of 23 marker trait association were identified with markers from Rc gene showed the strongest association with the three antioxidant traits. Rid12, RM484, RM162, RM5371 were commonly detected for phenolic content, flavonoids content and antioxidant capacity.

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References

  • Anderson JW (2003) Whole grains protect against atherosclerotic cardiovascular disease. Proc Nutr Soc 62:135–142

    Article  CAS  Google Scholar 

  • Agrama HA, Yan WG, Lee F, Fjellstrom R, Chen MH, Jia M, McClung A (2009) Genetic assessment of a mini-core subset developed from the USDA rice genebank. Crop Sci 49:1336–1346

    Article  Google Scholar 

  • Bao JS, Cai Y, Sun M, Wang GY, Corke H (2005) Anthocyanins, flavonols, and free radical scavenging activity of Chinese bayberry (Myrica rubra) extracts and their color properties and stability. J Agric Food Chem 53:2327–2332

    Article  CAS  Google Scholar 

  • Brotman Y, Llorente-Wiegand C, Oyong G, Badoni S, Misra G, Anacleto R, Parween S, Pasion E, Tiozon RN Jr, Anonuevo JJ, deGuzman MK, Alseekh S, Mbanjo EGN, Boyd LA, Fernie AR, Sreenivasulu N (2021) The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition. Plant J 106(2):507–525

    Article  CAS  Google Scholar 

  • Cai YZ, Luo Q, Sun M, Corke H (2004) Antioxidant activity and phenolic compounds of 112 traditional Chinese medical plants associated with anticancer. Life Sci 74:2157–2184

    Article  CAS  Google Scholar 

  • Dykes L, Rooney LW (2007) Phenolic compounds in cereal grains and their health benefits. Cereal Food World 52:105–111

    CAS  Google Scholar 

  • Goffman FD, Bergman CJ (2004) Rice kernel phenolic content and its relationship with antiradical efficiency. J Sci Food Agric 84:1235–1240

    Article  CAS  Google Scholar 

  • Goufo P, Trindade H (2014) Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sci Nutr 2:75–104

    Article  CAS  Google Scholar 

  • Hagerman AE, Riedl KM, Jones GA, Sovik KN, Ritchard NT, Hartzfeld PW, Riechel TL (1998) High molecular weight plant polyphenols (tannins) as biological antioxidants. J Agric Food Chem 46:1887

    Article  CAS  Google Scholar 

  • Hudson EA, Dinh PA, Kokubun T, Simmonds MSJ, Gescher A (2000) Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. Cancer Epidemiol Biomark Prev 9:1163–1170

    CAS  Google Scholar 

  • Jin L, Xiao P, Lu Y, Shao YF, Shen Y, Bao JS (2009) Quantitative trait loci for brown rice color, phenolics, flavonoid contents, and antioxidant capacity in rice grain. Cereal Chem 86:609–615

    Article  CAS  Google Scholar 

  • Kato S, Ishikawa J (1921) On the inheritance of the pigment of red rice. Jpn J Genet 1:1–7

    Article  CAS  Google Scholar 

  • Li K, Bao J, Harold C, Mei S (2017) Association analysis of markers derived from starch biosynthesis related genes with starch physicochemical properties in the USDA rice mini-core collection. Front Plant Sci 8:424

    PubMed  PubMed Central  Google Scholar 

  • Li XB, Yan WG, Agrama H, Hu BL, Jia LM, Jia M et al (2010) Genotypic and phenotypic characterization of genetic differentiation and diversity in the USDA rice mini-core collection. Genetica 138:1221–1230

    Article  CAS  Google Scholar 

  • Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134:3479S-3485S

    Article  CAS  Google Scholar 

  • Liu RH (2007) Whole grain phytochemicals and health. J Cereal Sci 46:207–219

    Article  CAS  Google Scholar 

  • Mir SA, Shah MA, Bosco SJD, Sunooj KV, Farooq S (2020) A review on nutritional properties, health aspects, shelf life and consumption of brown rice in comparison to white rice. Cereal Chem 97(5):895–903

    Article  Google Scholar 

  • Okater O, Liu RH (2010) Health benefits of whole grain rice phytochemicals. Crit Rev Food Sci Nutr 50:193–208

    Article  Google Scholar 

  • Oki T, Masuda M, Kobayashi M, Nishiba Y, Furuta S, Suda I, Sato T (2002) Polymeric procyanidins as radical-scavenging components in red-hulled rice. J Agric Food Chem 50:7524–7529

    Article  CAS  Google Scholar 

  • Reddy VS, Dash S, Reddy AR (1995) Anthocyanin pathway in rice (Oryza sativa L.): identification of a mutant showing dominant inhibition of anthocyanins in leaf and accumulation of proanthocyanidins in pericarp. Theor Appl Genet 91:301–312

    Article  CAS  Google Scholar 

  • Saleh SMA, Wang P, Wang N, Yang L, Xiao Z (2019) Brown rice versus white rice: nutritional quality, potential health benefits, development of food products, and preservation technologies. Compr Rev Food Sci F 18(4):1070–1096

    Article  Google Scholar 

  • Seal CJ (2006) Whole grains and CVD risk. Proc Nutr Soc 65:24–34

    Article  CAS  Google Scholar 

  • Shao Y, Jin L, Zhang G, Lu Y, Shen Y, Bao J (2011) Association mapping of grain color, phenolic content, flavonoid content and antioxidant capacity in dehulled rice. Theor Appl Genet 122:1005–1016

    Article  CAS  Google Scholar 

  • Shen Y, Jin L, Xiao P, Lu Y, Bao J (2009) Total phenolics, flavonoids, antioxidant capacity in rice grain and their relations to grain color, size and weight. J Cereal Sci 49:106–111

    Article  CAS  Google Scholar 

  • Sweeney MT, Thomson MJ, Pfeil BE, McCouch S (2006) Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice. Plant Cell 18:283–294

    Article  CAS  Google Scholar 

  • Tan YF, Sun M, Xing YZ, Hua JP, Xun XL, Zhang QF, Corke H (2001) Mapping quantitative trait loci for milling quality, protein content and color characteristics of rice using a recombinant inbred line population derived from an elite rice hybrid. Theor Appl Genet 103:1037–1045

    Article  CAS  Google Scholar 

  • Venn BJ, Mann JI (2004) Cereal grains, legumes and diabetes. Eur J Clin Nutr 58:1443–1461

    Article  CAS  Google Scholar 

  • Wang CX, Shu QY (2007) Fine mapping and candidate gene analysis of purple pericarp gene Pb in rice (Oryza sativa L.). Chin Sci Bull 52:3097–3104

    Article  CAS  Google Scholar 

  • Yokoyama W (2004) Nutritional properties of rice and rice bran. In: Champagne ET (ed) Rice chemistry and technology. AACC, St. Paul, pp 595–609

  • Yoshimura A, Ideta O, Iwana N (1997) Linkage map of phenotype and RFLP markers in rice. Plant Mol Biol 35:49–60

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Guizhou University Natural Science Project (2020) 23 and Guizhou University Seed Program (2020) 26 for financial support.

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    Authors and Affiliations

    1. Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology and Agro-Bioengineering (CICMEAB), Institute of Agro-Bioengineering, College of Life Sciences, Guizhou University, GuiyangGuizhou, 550025, China

      Kehu Li, Huanhuan Ren & Yongyi Ge

    2. Forestry and Pomology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai, 201106, People’s Republic of China

      Qingzhu Li

    3. Li Ka Shing, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, People’s Republic of China

      Lily Yan Wang

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    1. Kehu Li
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    Li, K., Li, Q., Wang, L.Y. et al. Genetic variation and association mapping of phenolic, flavonoid content and antioxidant capacity in USDA rice mini-core collection. Genet Resour Crop Evol 69, 1685–1694 (2022). https://doi.org/10.1007/s10722-021-01333-y

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