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Experimental Study of the Chromatographic Extraction Process of Separation in a Closed Multistage Loop

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Abstract

Results of an experimental study on a semibatch multistage chromatographic extraction process for the separation of a binary mixture of components in a multistage setup with eluent recycling under different mixture-loading conditions are presented.

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REFERENCES

  1. Müller, M., Wasmer, K., and Vetter, W., Multiple injection mode with or without repeated sample injections: Strategies to enhance productivity in countercurrent chromatography, J. Chromatogr. A, 2018, vol. 1556, pp. 88–96. https://doi.org/10.1016/j.chroma.2018.04.069

    Article  CAS  PubMed  Google Scholar 

  2. Chami, M.C., Bouju, E., Lequemener, C., de Vaumas, R., Hadji-Minaglou, F., Fernandez, X., and Michel, T., Purification of two valepotriates from Centranthus ruber by centrifugal partition chromatography: From analytical to preparative scale, J. Chromatogr. A, 2018, vol. 1580, pp. 126–133. https://doi.org/10.1016/j.chroma.2018.10.044

    Article  CAS  Google Scholar 

  3. Huang, X.-Y., Pei, D., Liu, J.-F., and Di, D.-L., A review on chiral separation by counter-current chromatography: Development, applications and future outlook, J. Chromatogr. A, 2018, vol. 1531, pp. 1–12. https://doi.org/10.1016/j.chroma.2017.10.073

    Article  CAS  PubMed  Google Scholar 

  4. Fang, Y., Li, Q., Shao, Q., Wang, B., and Wei, Y., A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn, J. Chromatogr. A, 2017, vol. 1507, pp. 63–71. https://doi.org/10.1016/j.chroma.2017.05.048

    Article  CAS  PubMed  Google Scholar 

  5. Sutherland, I.A., Hewitson, P., Siebers, R., van den Heuvel, R., Arbenz, L., Kinkel, J., and Fisher, D., Scale-up of protein purifications using aqueous two-phase systems: Comparing multilayer toroidal coil chromatography with centrifugal partition chromatography, J. Chromatogr. A, 2011, vol. 1218, pp. 5527–5530. https://doi.org/10.1016/j.chroma.2011.04.013

    Article  CAS  PubMed  Google Scholar 

  6. Wang, Y., Zhang, L., Zhou, H., Guo, X., and Wu, S., K-targeted strategy for isolation of phenolic alkaloids of Nelumbo nucifera Gaertn by counter-current chromatography using lysine as a pH regulator, J. Chromatogr. A, 2017, vol. 1490, pp. 115–125. https://doi.org/10.1016/j.chroma.2017.02.022

    Article  CAS  PubMed  Google Scholar 

  7. Boonloed, A., Weber, G.L., Ramzy, K.M., Dias, V.R., and Remcho, V.T., Centrifugal partition chromatography: A preparative tool for isolation and purification of xylindein from Chlorociboria aeruginosa, J. Chromatogr. A, 2016, vol. 1478, pp. 19–25. https://doi.org/10.1016/j.chroma.2016.11.026

    Article  CAS  PubMed  Google Scholar 

  8. Berthod, A., Friesen, J.B., Inui, T., and Pauli, G.F., Elution–extrusion countercurrent chromatography:  Theory and concepts in metabolic analysis, Anal. Chem. (Washington, DC, U. S.), 2007, vol. 79, no. 9, pp. 3371–3382. https://doi.org/10.1021/ac062397g

    Article  CAS  Google Scholar 

  9. Kostanyan, A.E. and Voshkin, A.A., Support-free pulsed liquid–liquid chromatography, J. Chromatogr. A, 2009, vol. 1216, no. 45, pp. 7761–7766. https://doi.org/10.1016/j.chroma.2009.09.007

    Article  CAS  PubMed  Google Scholar 

  10. Kostanyan, A.E. and Erastov, A.A., Steady state preparative multiple dual mode counter-current chromatography: Productivity and selectivity. Theory and experimental verification, J. Chromatogr. A, 2015, vol. 1406, pp. 118–128. https://doi.org/10.1016/j.chroma.2015.05.074

    Article  CAS  PubMed  Google Scholar 

  11. Kostanyan, A., Martynova, M., Erastov, A., and Belova, V., Simultaneous concentration and separation of target compounds from multicomponent mixtures by closed-loop recycling countercurrent chromatography, J. Chromatogr. A, 2018, vol. 1560, pp. 26–34. https://doi.org/10.1016/j.chroma.2018.05.032

    Article  CAS  PubMed  Google Scholar 

  12. Martynova, M.M., Kostanyan, A.E., and Tsareva, Yu.V., Investigation into the extraction–chromatographic separation of a binary mixture in a series of multistage columns, Theor. Found. Chem. Eng., 2019, vol. 53, pp. 950–953. https://doi.org/10.1134/S0040579519050142

    Article  CAS  Google Scholar 

  13. Conway, W.D., Countercurrent Chromatography: Apparatus, Theory and Applications, New York: VCH, 1990.

    Google Scholar 

  14. Ito, Y., Golden rules and pitfalls in selecting optimum conditions for high-speed counter-current chromatography, J. Chromatogr. A, 2005, vol. 1065, pp. 145–168. https://doi.org/10.1016/j.chroma.2004.12.044

    Article  CAS  PubMed  Google Scholar 

  15. Friesen, J.B., McAlpine, J.B., Chen, S.-N., and Pauli, G.F., Countercurrent separation of natural products: An update, J. Nat. Prod., 2015, vol. 78, no. 7, pp. 1765–1796. https://doi.org/10.1021/np501065h

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Ignatova, S. and Sutherland, I., The 8th International Conference on Counter-Current Chromatography held at Brunel University, London, UK, July 23–25, 2014, J. Chromatogr. A, 2015, vol. 1425, pp. 1–7. https://doi.org/10.1016/j.chroma.2015.10.096

    Article  CAS  PubMed  Google Scholar 

  17. Rozen, A.M. and Kostanyan, A.E., Enhanced extractors: An element approach, modeling, calculation, and prospects for the development of new high-efficiency designs, Zh. Prikl. Khim., 1986, vol. 59, no. 9, pp. 2083–2090.

    CAS  Google Scholar 

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Funding

This work was performed as part of a state task of the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, in the field of fundamental sciences. Financial support was provided in part by the Russian Foundation for Basic Research (project no. 18-33-00081 mol_a).

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    M. M. Martynova & A. E. Kostanyan

  2. Mendeleev Mendeleev University of Chemical Technology of Russia, Moscow, 125047, Moscow, Russia

    A. G. Apostolov

Authors
  1. M. M. Martynova
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  2. A. G. Apostolov
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  3. A. E. Kostanyan
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Corresponding author

Correspondence to M. M. Martynova.

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Translated by E. Glushachenkova

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Martynova, M.M., Apostolov, A.G. & Kostanyan, A.E. Experimental Study of the Chromatographic Extraction Process of Separation in a Closed Multistage Loop. Theor Found Chem Eng 55, 1107–1110 (2021). https://doi.org/10.1134/S0040579520050176

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  • DOI: https://doi.org/10.1134/S0040579520050176

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