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Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors

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Abstract

Cardiomyocytes are essential to maintain the normal cardiac function. Ischemia, hypoxia, and drug stimulation can induce pathological apoptosis of cardiomyocytes which eventually leads to heart failure, arrhythmia, and other cardiovascular diseases. Understanding the molecular mechanisms that regulate cardiomyocyte apoptosis is of great significance for the prevention and treatment of cardiovascular diseases. In recent years, more and more evidences reveal that long noncoding RNAs (lncRNAs) play important regulatory roles in myocardial cell apoptosis. They can modulate the expression of apoptosis-related genes at post-transcriptional level by altering the translation efficacy of target mRNAs or functioning as a precursor for miRNAs or competing for miRNA-mediated inhibition. Moreover, reversing the abnormal expression of lncRNAs can attenuate and even reverse the pathological apoptosis of cardiomyocytes. Therefore, apoptosis-related lncRNAs may become a potential new field for studying cardiomyocyte apoptosis and provide new ideas for the treatment of cardiovascular diseases.

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Funding

This study was funded by the National Natural Sciences Foundation of China (grant number 81874410).

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Authors and Affiliations

  1. National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

    Jinghui Sun, Ru Wang, Tiantian Chao & Chenglong Wang

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  1. Jinghui Sun
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  2. Ru Wang
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  3. Tiantian Chao
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  4. Chenglong Wang
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Correspondence to Chenglong Wang.

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Associate Editor Junjie Xiao oversaw the review of this article.

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Sun, J., Wang, R., Chao, T. et al. Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors. J. of Cardiovasc. Trans. Res. 15, 588–603 (2022). https://doi.org/10.1007/s12265-021-10186-w

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