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Multi-parametric evaluation of ocular surface disorders during healing process of viral conjunctivitis

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Abstract

Purpose To evaluate the ocular surface properties in epidemic keratoconjunctivitis (EKC) patients during healing process, and to detect the damage on conjunctival goblet cells. Methods Bilateral EKC patients confirmed with polymerase chain reaction (PCR) testing were included. Firstly (Group 1) and secondly (Group 2) affected eyes were compared. Ocular surface parameters were performed at the first visit and first month. Results The study included 34 eyes of 17 patients. The mean age was 44.54 ± 16.80 (21–70) years (FM/M 20/14). The ocular findings in Groups 1 and 2 were not significant. For Groups 1 and 2, OSDI was 53.53 ± 23.01 and 35.90 ± 22.19 (p 0.03), tear osmolarity was 309.12 ± 19.38 and 297.47 ± 8.27 mOsm/µL (p 0.029), OSSS was 1.00 ± 0.79 and 0.18 ± 0.39 (p 0.001), T-BUT was 3.59 ± 2.29 and 6.00 ± 1.83 s (p 0.002), and Schirmer’s 1 test was 10.94 ± 8.42 and 16.76 ± 9.05 mm (p 0.061), respectively. In Groups 1 and 2, the IC was Grade (G) 0 in 23.5% and 17.6%, G1 in 35.3% and 41.2%, and G2 in 41.2% and 41.2%, respectively. The ocular surface properties were worse in Group 1 than Group 2, and the difference was significant except for Schirmer’s 1 test and IC. Conclusions Dry eye disorder is a complication of EKC and may cause a significant decrease in quality of life.

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Authors and Affiliations

  1. Department of Ophthalmology, Balıkesir University Medicine Faculty, 10045, Balıkesir, Turkey

    Gozde Sahin Vural

  2. Department of Ophthalmology, Ege University Medicine Faculty, Izmir, Turkey

    Ozlem Barut Selver & Melis Palamar

  3. Department of Pathology, Ege University Medicine Faculty, Izmir, Turkey

    Ali Veral

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  1. Gozde Sahin Vural
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Contributions

GSV performed the data collection; MP and OBS were involved in planning and supervised the work; OBS, MP, and GSV processed the experimental data, performed the analysis, drafted the manuscript, and designed the tables and graphics. All authors discussed the results and commented on the manuscript.

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Correspondence to Gozde Sahin Vural.

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The authors declare that they have no conflict of interest.

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The data supporting our findings can be found at Ege University, Faculty of Medicine, Ophthalmology Department.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration Helsinki and its later amendments or comparable ethical standards. The study was approved by Ege University, Faculty of Medicine, Surgical and Pharmaceutical Research Ethics Board (IRB: 2019/0511).

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Sahin Vural, G., Barut Selver, O., Veral, A. et al. Multi-parametric evaluation of ocular surface disorders during healing process of viral conjunctivitis. Int Ophthalmol 42, 1419–1425 (2022). https://doi.org/10.1007/s10792-021-02130-3

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