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Study on rapid modeling and manufacturing method of porous bone scaffold based on voxel model

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Abstract

For solving the modeling problem of porous structure design of bone scaffold, a modeling method of porous bone scaffold based on voxel model was proposed. Firstly, the surface of model triangular facets of bone scaffold was reconstructed by moving cube (MC) algorithm with the computer tomographic (CT) images. Secondly, a rapidly slicing algorithm based on surface model was proposed to obtain the cross-sectional profile of bone scaffold. Then, an isometric scanning line of cross-sectional profile was filled and dispersed to construct voxel model; subsequently, the pore unit was designed based on voxel, and the voxel model of porous bone scaffold was constructed by filling the pore units; finally, combined with additive manufacturing process, a method to generate processing path directly based on the voxel model was proposed. It can be concluded from the experiment that the porous bone scaffold could be constructed by the proposed algorithm. The parameters including pore size and porosity on the bone scaffold could be controlled through adjusting the voxel size and pore unit structures. The processing path was obtained directly from the voxel model, thus providing a feasible method for the design and manufacture of the porous bone scaffold.

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References

  1. Liang JH, Li RY, Liu GC et al (2017) Design of the porous orthopedic implants: research and application status. Ch J Tissue Eng Res 21(15):2410–2417

    Google Scholar 

  2. Surmeneva M, Surmenev R, Chudinova E, Koptioug A, Tkachev M, Gorodzha LE (2017) Fabrication of multiple-layered gradient cellular metal scaffold via electron beam melting for segmental bone reconstruction. Mater Des 133:195–204

    Article  Google Scholar 

  3. Han N, Zhao J (2010) The development of scaffolds in cartilage tissue engineering [J]. J Med Postgrad 23(01):94–96

    Google Scholar 

  4. Gui H, Li P, Zhang W (2013) Materials and methods for preparation of tissue-engineered cartilage Scaffolds[J]. J Clin Rehabil Tissue Eng Res 17(3):509–516

    Google Scholar 

  5. Heinl P, Müller L, Körner C, Singer RF, Müller FA (2008) Cellular Ti-6Al-4Vstructures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. Acta Biomater 4:1536–2154

    Article  Google Scholar 

  6. Mullen L, Stamp RC, Brooks WK, Jones E, Sutclife CJ (2009) Selective laser melting: a regular unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications. J Biomed Mater Res B Appl Biomater 89:325–334

    Article  Google Scholar 

  7. Campoli G, Borlefs M, Amin Yavari S, Wauthle R, Weinans H, Zadpoor AA (2013) Mechanical properties of open-cell metallic biomaterials manufactured using additive manufacturing. Mater Des 49:957–965

    Article  Google Scholar 

  8. Jin JC, Wang Y, Ma WH, Zhu YB (2016) Application progresses of 3D-bioprinting technology in scaffold constitution for tissue engineering and tissue regeneration. Space Med Med Eng 29(06):462–468

    Google Scholar 

  9. Shao HF, He Y, Fu JZ (2018) Research advance of degradable artificial bone with additive manufacturing: customization from geometric shape to property. J Zhejiang Univ 03:1–22

    Google Scholar 

  10. Top N, Sahin İ, Gokce H, Gokce H (2021) Computer-aided design and additive manufacturing of bone scaffolds for tissue engineering: state of the art. J Mater Res. https://doi.org/10.1557/s43578-021-00156-y

    Article  Google Scholar 

  11. Khanaki HR, Rahmati S, Nikkhoo M (2020) Numerical and analytical simulation of multilayer cellular scaffolds. J Braz Soc Mech Sci Eng 42:268

    Article  Google Scholar 

  12. Yan RZ, Luo DM, Qin XY (2016) Digital modeling for the individual mandibular 3D mesh scaffold based on 3D printing technology. Ch J Stomatol 51(5):280–285

    Google Scholar 

  13. Cai S, Xi J (2008) A control approach for pore size distribution in the bone scaffold based on the hexahedral mesh refinement. Comput Aided Design-London-Butterworth then Elsevier 40(10–11):1040–1050

    Article  Google Scholar 

  14. Cai S,Xi J,Chua C K (2012) A Novel Bone Scaffold Design Approach Based 011 Shape Function and All-Hexahedral Mesh Refinement//Computer-Aided Tissue Engineering Humana Press: 45–55

  15. You F, Yao Y, Qingxi HU (2011) Generation and evaluation of porous structure of bionic bone scaffold. J Mech Eng 47(01):138–144

    Article  Google Scholar 

  16. You F, Hu QX, Zhu XJ (2013) Integrated evaluation inner structure performance of regenerative bone scaffold. Ch Mech Eng 24(20):2768–2774

    Google Scholar 

  17. Cheah CM, Chua CK, Leong KF et al (2003) Development of a tissue engineering scaffold structure library for rapid prototyping. Part 1: investigation and classification. Int J Adv Manuf Technol 21(4):291–301

    Article  Google Scholar 

  18. Cheah CM, Chua CK, Leong KF et al (2003) Development of a tissue engineering scaffold structure library for rapid prototyping. Part 2: parametric library and assembly program. Int J Adv Manuf Technol 21(4):302–312

    Article  Google Scholar 

  19. Cheah CM, Chua CK, Leong KF et al (2004) Automatic algorithm for generating complex polyhedral scaffold structures for tissue engineering. Tissue Eng 10(3–4):595–610

    Article  Google Scholar 

  20. Naing MW, Chua CK, Leong KF et al (2005) Fabrication of customised scaffolds using computer-aided design and rapid prototyping techniques. Rapid Prototyp J 11(4):249–259

    Article  Google Scholar 

  21. Naing MW, Chua CK, Leong KF (2008) Computer aided tissue engineering scaffold fabrication //Virtual prototyping & bio manufacturing in medical applications. Springer, US, New York, pp 67–85

    Book  Google Scholar 

  22. Chantarapanich N, Puttawibul P, Sucharitpwatskul S et al (2012) Scaffold library for tissue engineering: a geometric evaluation. Comput Math Methods Med 3:565–569

    MathSciNet  MATH  Google Scholar 

  23. You Y H, Kou S T, Tan S T (2016) A new approach for irregular porous structure modeling based on centroidal Voronoi tessellation and B-spline. Comput-Aided Design Appl: 484–489

  24. Li H, Luo Z, Gao L et al (2018) Topology optimization for concurrent design of structures with multi-patch microstructures by level sets. Comput Methods Appl Mech Eng 331:536–561

    Article  MathSciNet  Google Scholar 

  25. Fu JJ, Xia L, Gao L et al (2019) Topology optimization of periodic structures with substructuring. J Mech Design 141(7):071403

    Article  Google Scholar 

  26. Almeida HA, Bártolo PJ (2014) Design of tissue engineering scaffolds based on hyperbolic surfaces: Structural numerical evaluation. Med Eng Phys 36:1033–1040

    Article  Google Scholar 

  27. Qinghui WANG, Gang XIA, Zhijia XU et al (2016) Modelling the microstructures of cancellous bone based on triply periodic minimal surface for tissue engineering. J Comput-Aided Design Comput Gr 28(11):1949–1956

    Google Scholar 

  28. Castro APG, Ruben RB, Gonçalves SB et al (2019) Numerical and experimental evaluation of TPMS Gyroid scaffolds for bone tissue engineering. Comput Methods Biomech Biomed Engin 22(6):567–573

    Article  Google Scholar 

  29. Maszybrocka J, Gapiński B, Dworak M et al (2019) The manufacturability and compression properties of the Schwarz Diamond type Ti6Al4V cellular lattice fabricated by selective laser melting. Int J Adv Manuf Technol 105(7):3411–3425

    Article  Google Scholar 

  30. Zhang XY, Fang G, Leeflang S et al (2019) Topological design, permeability and mechanical behavior of additively manufactured functionally graded porous metallic biomaterials. Acta Biomater 84:437–452

    Article  Google Scholar 

  31. Ruining GAO, Xiang LI et al (2019) Design and mechanical properties analysis of radially graded porous scaffolds. J Mech Eng 57(3):220–226

    Google Scholar 

  32. Abou-Ali AM, Al-Ketan O, Rowshan R et al (2019) Mechanical response of 3D printed bending-dominated ligament-based triply periodic cellular polymeric solids. J Mater Eng Perform 28(4):2316–2326

    Article  Google Scholar 

  33. Lorensen WE, Cline HE (1987) Marching cubes: A high resolution 3D surface construction algorithm. ACM Siggraph Computer Graphics 21(4):163–169

    Article  Google Scholar 

  34. Yu WW, He F, Xi P (2010) Improvement of MC method for 3D reconstructed model based on spine CT images. Comput Eng Appl 46(2):25–28

    Google Scholar 

  35. Mao Y, Chen ZB (2007) Bionic design of human bone microstructure based on fractal theory. Ch J Tissue Eng Res 14:2784–2786

    Google Scholar 

  36. Mao Y, Chen Z B, et al (2004) 3D Bionics Artificial Bone Design Based on Medical Images. Ch J Stereol Image Anal (03): 160–163+172

  37. Kou XY, Tan ST (2010) A simple and effective geometric representation for irregular porous structure modeling. Comput Aided Des 42(10):930–941

    Article  Google Scholar 

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Acknowledgements

The project was supported by the National Science Foundation for postdoctoral (No. 51605145) and Henan Province key science and technology research project (No. 51605145).

Funding

National Natural Science Funds for Young Scholars of China(CN),51605145,Li Yao-song

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Authors and Affiliations

  1. School of Mechatronics Engineering, Henan University of Science and Technology, Luoyang, 471003, Henan, China

    Zhuang-ya Zhang, Yao-song Li & Ming-de Duan

  2. School of Mechanical Engineering, Yangtze University, Jingzhou, 434023, China

    Li-ming Ou

  3. Luoyang Center for Quality Metrology and Testing, Luoyang, 471000, Henan, China

    Jing Zhang

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  1. Zhuang-ya Zhang
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  2. Li-ming Ou
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  3. Jing Zhang
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  4. Yao-song Li
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Correspondence to Zhuang-ya Zhang.

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Technical Editor: Adriano Almeida Gonçalves Siqueira.

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Zhang, Zy., Ou, Lm., Zhang, J. et al. Study on rapid modeling and manufacturing method of porous bone scaffold based on voxel model. J Braz. Soc. Mech. Sci. Eng. 43, 566 (2021). https://doi.org/10.1007/s40430-021-03289-7

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  • DOI: https://doi.org/10.1007/s40430-021-03289-7

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