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Genetic ancestry and racial differences in prostate tumours

Nature Reviews Urology volume 19, pages 133–134 (2022)Cite this article

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A striking disproportionate burden of prostate cancer incidence and mortality exists between men of West African ancestry and men of European ancestry. Identifying distinct tumour genetic biomarkers and immunomodulating signals in patients with diverse genetic ancestry might reduce the disparities in prostate cancer prognosis, treatment outcomes and mortality in high-risk racial groups.

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References

  1. Badal, S. et al. Disparities in prostate cancer incidence and mortality rates: solvable or not? Prostate 80, 3–16 (2020).

    Article  Google Scholar 

  2. Batai, K., Hooker, S. & Kittles, R. A. Leveraging genetic ancestry to study health disparities. Am. J. Phys. Anthropol. 175, 363–375 (2021).

    Article  Google Scholar 

  3. Liu, W. et al. A CD24-p53 axis contributes to African American prostate cancer disparities. Prostate 80, 609–618 (2020).

    Article  CAS  Google Scholar 

  4. Yamoah, K. et al. Prostate tumors of native men from West Africa show biologically distinct pathways—a comparative genomic study. Prostate 81, 1402–1410 (2021).

    Article  CAS  Google Scholar 

  5. Koga, Y. et al. Genomic profiling of prostate cancers from men with African and European ancestry. Clin. Cancer. Res. 26, 4651–4660 (2020).

    Article  CAS  Google Scholar 

  6. Graff, R. E. et al. The TMPRSS2:ERG fusion and response to androgen deprivation therapy for prostate cancer. Prostate 75, 897–906 (2015).

    Article  CAS  Google Scholar 

  7. Semaan, L., Mander, N., Cher, M. L. & Chinni, S. R. TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model. BMC Cancer 19, 972 (2019).

    Article  Google Scholar 

  8. Jamaspishvili, T. et al. Clinical implications of PTEN loss in prostate cancer. Nat. Rev. Urol. 15, 222–234 (2018).

    Article  CAS  Google Scholar 

  9. Nagle, R. B. et al. ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. Prostate 73, 1233–1240 (2013).

    Article  CAS  Google Scholar 

  10. Sartor, O. et al. Survival of African-American and Caucasian men after sipuleucel-T immunotherapy: outcomes from the PROCEED registry. Prostate Cancer Prostatic Dis. 23, 517–526 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Health Equities, Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    Jabril R. Johnson & Rick A. Kittles

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  1. Jabril R. Johnson
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  2. Rick A. Kittles
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Correspondence to Rick A. Kittles.

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The authors declare no competing interests.

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Johnson, J.R., Kittles, R.A. Genetic ancestry and racial differences in prostate tumours. Nat Rev Urol 19, 133–134 (2022). https://doi.org/10.1038/s41585-021-00544-3

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