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Amyotrophic lateral sclerosis is over-represented in two Huntington’s disease brain bank cohorts: further evidence to support genetic pleiotropy of pathogenic HTT gene expansion

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Acknowledgements

RAH was supported by grant funding from the Huntington Disease Society of America and Hereditary Disease Foundation and was a Columbia University Irving Medical Center ADRC Research Education Component trainee (P30 AG066462-01 PI: Small, Scott, MD). The New York Brain Bank is supported by P50 AG008702 (PI Scott Small, MD). We extend our gratitude to the patients, families, and caregivers who were critical for accomplishing this study and the Essential Tremor Centralized Brain Repository (co-PIs Elan Louis, MD and Phyllis L. Faust, MD, PhD). This work was supported in part by the Intramural Research Programs of the NIH, National Institute on Aging (Z01-AG000949-02).

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Richard A. Hickman

  2. Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, 630 W 168th Street, New York, NY, 10032, USA

    Richard A. Hickman & Jean-Paul Vonsattel

  3. Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA

    Ramita Dewan & Bryan J. Traynor

  4. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Etty Cortes

  5. Department of Neurology and Psychiatry, Columbia University Irving Medical Center, New York, USA

    Karen Marder

  6. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 710 West 168th Street, New York, NY, 10032, USA

    Karen Marder & Jean-Paul Vonsattel

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  1. Richard A. Hickman
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  2. Ramita Dewan
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  3. Etty Cortes
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  4. Bryan J. Traynor
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  5. Karen Marder
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  6. Jean-Paul Vonsattel
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Correspondence to Richard A. Hickman.

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Hickman, R.A., Dewan, R., Cortes, E. et al. Amyotrophic lateral sclerosis is over-represented in two Huntington’s disease brain bank cohorts: further evidence to support genetic pleiotropy of pathogenic HTT gene expansion. Acta Neuropathol 143, 105–108 (2022). https://doi.org/10.1007/s00401-021-02385-1

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  • DOI: https://doi.org/10.1007/s00401-021-02385-1

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