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PUMCH experience and strategy for the management of idiopathic macular hole: a retrospective cohort study

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Abstract

Purpose

To introduce and evaluate a modified therapeutic strategy for idiopathic macular holes (IMH).

Methods

A retrospective review of patients with diagnosis of IMH from July 2016 to January 2020 at Peking Union Medical College Hospital. These patients were managed strictly according to our therapeutic strategy. Their comprehensive clinical data were collected and analyzed.

Results

209 eyes suffering stage II to IV IMH were identified. For stage II IMH, the spontaneous closure rate was 8.9%, the initial success rate of intravitreal injections (IVI) of expansile gas and pars plana vitrectomy (PPV) + internal limiting membrane peeling (ILMP) + air tamponade was 84.2% and 100%, respectively. The initial success rate of PPV + ILMP + air tamponade for stage III and stage IV IMH was 89.8% and 86.4%, respectively. Following our intervention strategy, stage II IMH achieved a final IMH closure rate of 100%, stage III of 99% and stage IV of 97%. The final best corrected visual acuity was significantly improved (P < 0.05). Sitting position air-fluid (A-F) exchange alone successfully induced IMH closure in 7/19 eyes that did not achieve IMH closure by initial PPV. For three refractory cases that failed additional PPV + ILM stuffing, intraoperative OCT assisted PPV + sub-retinal BSS injection successfully induced the IMH closure. As the remaining three unclosed IMH cases were dry and stable, no more interventions were conducted.

Conclusion

The general IMH closure rate based on our therapeutic strategy was satisfactory with a favorable prognosis. IVI expansile gas and sitting position A-F exchange were effective and highly cost-effective under certain circumstances.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

Abbreviations

A-F:

Air-fluid

BCVA:

Best corrected visual acuity

BSS:

Balanced salt solution

CME:

Cystoid macular edema

CRTP:

Central retinal thickness

ELM:

External limiting membrane

ILMP:

Internal limiting membrane peeling

IMH:

Idiopathic macular holes

IOP:

Intraocular pressure

IVI:

Intravitreal injections

logMAR:

Logarithm of the minimum angle of resolution

C3F8:

Octafluoropropane

OCT:

Optical coherence tomography

PPV:

Pars plana vitrectomy

PVD:

Posterior vitreous detachment

SF6:

Sulfur hexafluoride

VMT:

Vitreo-macular traction

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Funding

The authors declare that they have no funding sources.

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Authors and Affiliations

Authors

Contributions

X-yZ and L-hM carried out the entire procedure including the collection of medical records, image evaluation, statistical analysis, drafting the manuscript and manuscript revision. Wen-fei Zhang and Wei-hong Yu helped draft and revise the manuscript. Han-yi Min conceived of the study, coordinated and participated in the entire process of drafting and revised the manuscript. You-xin Chen contributed to image evaluation and manuscript revision. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to You-xin Chen or Han-yi Min.

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Conflict interests

All authors have contributed significantly and are in agreement with the content of the manuscript. No author has any relevant financial relationship to disclose.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This retrospective study was approved by the Institutional Review Board/Ethics Committee of Peking Union Medical College Hospital.

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Informed consent to participate was obtained from all individual participants included in the study.

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Informed consent to participate was obtained from all individual participants included in the study.

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Zhao, Xy., Meng, Lh., Zhang, Wf. et al. PUMCH experience and strategy for the management of idiopathic macular hole: a retrospective cohort study. Int Ophthalmol 42, 1133–1145 (2022). https://doi.org/10.1007/s10792-021-02099-z

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  • DOI: https://doi.org/10.1007/s10792-021-02099-z

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