AOS ThesisMolecular and Clinical Characterization of Human Adenovirus E4–Associated Conjunctivitis
Section snippets
PARTICIPANTS
This prospective study was conducted with Goodwin University Institutional Review Board approval (Cincinnati, Ohio, USA). In addition, local approval at all sites was obtained (including Drug Controller General in India, Scientific and Ethical Review Board, Faculty of Medicine, University of Kelaniya, Colombo, Sri Lanka, and National Ethics Committee in Research review in Brazil). All research was conducted in accord with to the tenets of the Declaration of Helsinki, applicable privacy laws,
PATIENT DEMOGRAPHICS AND PRESENTING SIGNS AND SYMPTOMS
Overall demographics of patients in the NVC-422 clinical trial have been presented previously.13 In the current study, we focused on those patients with PCR evidence for AdV E4 compared with those with AdV D8 (Table 1). A total of 36 subjects were PCR-positive for Adv E4 compared with 262 who tested positive for AdV D8. The mean age was similar between groups (33.6 ± 16.8 years for AdV E4, 34.2 ± 11.7 years for AdV D8, P = .81). Only 4 subjects among the 298 were <18 years of age, 3 of 36 in
DISCUSSION
Human adenovirus was first isolated from adenoid tissue (hence the name) by Rowe and associates in 1953.22 Adenoviruses are double-stranded, nonenveloped DNA viruses in the Mastadenovirus family. Adenoviruses are largely confined to humans23 and are believed to be the causative agent for a wide range of diseases, including mucosal diseases of the respiratory, genitourinary, and gastrointestinal tracts, neurologic infections, as well as ocular surface infections.
Viral typing has traditionally
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