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ADIPOSE TISSUE

Functional diversity of human adipose tissue revealed by spatial mapping

Nature Reviews Endocrinology volume 17, pages 713–714 (2021)Cite this article

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By mapping the spatial organization of adipose tissue, Bäckdahl and colleagues identify adipocyte progenitor structures as well as three subclasses of adipocytes with different molecular functions, including insulin sensitivity and leptin signalling.

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Fig. 1: Mapping the microarchitecture of human adipose tissue.

References

  1. Sakaguchi, M. et al. Adipocyte dynamics and reversible metabolic syndrome in mice with an inducible adipocyte-specific deletion of the insulin receptor. Cell Metab. 25, 448–462 (2017).

    Article  CAS  Google Scholar 

  2. Shao, M. et al. De novo adipocyte differentiation from Pdgfrβ + preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 9, 890 (2018).

    Article  Google Scholar 

  3. Schwalie, P. C. et al. A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature 559, 103–108 (2018).

    Article  CAS  Google Scholar 

  4. Merrick, D. et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science 364, eaav2501 (2019).

    Article  CAS  Google Scholar 

  5. Sárvári, A. K. et al. Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab. 33, 437–453 (2021).

    Article  Google Scholar 

  6. Sun, W. et al. snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature 587, 98–102 (2020).

    Article  CAS  Google Scholar 

  7. Min, S. Y. et al. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells. Proc. Natl Acad. Sci. USA 116, 17970–17979 (2019).

    Article  CAS  Google Scholar 

  8. Bäckdahl, J. et al. Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin. Cell Metab. 33, 1869–1882 (2021).

    Article  Google Scholar 

  9. Hepler, C., Vishvanath, L. & Gupta, R. K. Sorting out adipocyte precursors and their role in physiology and disease. Genes Dev. 31, 127–140 (2017).

    Article  CAS  Google Scholar 

  10. Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A. & Clement, K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868–877 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Camilla Scheele

  2. ETH Zürich, Department of Health Science and Technologies, Schwerzenbach, Switzerland

    Christian Wolfrum

Authors
  1. Camilla Scheele
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  2. Christian Wolfrum
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Correspondence to Christian Wolfrum.

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The authors declare no competing interests.

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Scheele, C., Wolfrum, C. Functional diversity of human adipose tissue revealed by spatial mapping. Nat Rev Endocrinol 17, 713–714 (2021). https://doi.org/10.1038/s41574-021-00582-2

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