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Preparation of Citric Acid-Locust Bean Gum (CA-LBG) for the Disintegrating Agent of Tablet Dosage Forms

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Abstract

Purpose

Analyze the effect of HCl concentration 0.24 mol as a synthesis catalyst on the viscosity of CA-LBG and determine the effect of the application of CA-LBG as a disintegrating agent on the physical quality of tablets.

Methods

Citric acid-locust bean gum (CA-LBG) was synthesized from citric acid (CA) and locust bean gum (LBG) using hydrochloric acid (HCl) and ultraviolet irradiation (UV 254 nm, 100 min). The CA-LBG was analyzed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), esterification efficiency, solubility, and viscosity. The tablet formulation used CA-LBG with a concentration variation of 0.5%, 1%, 2%, 4%, 8%, and 12%. Preparation of tablets by direct compression uses a spray dray lactose (SDL) as a filler with a tablet weight of 200 mg.

Results

Synthesis conditions using 0.24 mol HCl to produce CA-LBG 9.48 cP. The presence of CA-LBG as a disintegrating agent has variation effects to thickness, break force, tensile strength, and friability according to the concentration used. In the formulation process, increasing the concentration of CA-LBG in the tablet mass decreased the flow rate and increased compressibility.

Conclusion

The increase in the concentration of CA-LBG in tablets accelerated the disintegration of tablets without the influence of other tablet parameters. The CA-LBG disintegration activity through repulsion between CA-LBG deformations on the tablet when wetted with disintegration medium. The repulsion force occurs due to the character of CA-LBG which has low solubility and low viscosity.

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Acknowledgements

The authors thank the research, technology, and higher education department, Indonesia, for support of this work by providing research grants (0299/E3/2016). The author also thanks PT. Makmur Food (Indonesia) for supporting locust bean gum (Viscogum); LPPT Gadjah Mada University (Indonesia) for the SEM, DSC, and NMR instrument support; Faculty of Pharmacy, Gadjah Mada University (Indonesia), for support of pharmaceutical technology facilities; and Faculty of Pharmacy, Widya Mandala Catholic University Surabaya (Indonesia), for pharmaceutical technology facilities and instruments.

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Authors and Affiliations

  1. Department of Pharmaceutical, Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Kalisari Selatan no. 1 Pakuwon City, Surabaya, Indonesia

    Wuryanto Hadinugroho

  2. Department of Pharmaceutical, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia

    Wuryanto Hadinugroho, Suwaldi Martodihardjo, Achmad Fudholi & Sugeng Riyanto

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  1. Wuryanto Hadinugroho
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  2. Suwaldi Martodihardjo
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Contributions

Wuryanto Hadinugroho conceived and designed the experiments; performed the experiments; analyzed and interpreted the data; contributed reagents, materials, analysis tools, or data; and wrote the paper.

Suwaldi Martodihardjo, Achmad Fudholi, and Sugeng Riyanto conceived and designed the experiments and analyzed and interpreted the data.

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Correspondence to Wuryanto Hadinugroho.

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Hadinugroho, W., Martodihardjo, S., Fudholi, A. et al. Preparation of Citric Acid-Locust Bean Gum (CA-LBG) for the Disintegrating Agent of Tablet Dosage Forms. J Pharm Innov 17, 1160–1175 (2022). https://doi.org/10.1007/s12247-021-09591-0

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