Original articlesRates of Circumpapillary Retinal Nerve Fiber Layer Thinning and Capillary Density Loss in Glaucomatous Eyes with Disc Hemorrhage
Section snippets
METHODS
In this observational cohort study, subjects were enrolled from the Diagnostic Innovations Glaucoma Study (DIGS), a prospective longitudinal study designed to evaluate structural and functional changes in glaucoma. Participants were assessed longitudinally according to a pre-established protocol consisting of regular follow-up visits with clinical examination, imaging, and functional tests. All participants from the DIGS study who met the inclusion criteria described below were included in the
RESULTS
In this study, 34 eyes with DH and 134 eyes without DH that had ≥1.5 years of follow-up and 3 OCTA follow-up scans were enrolled. Initial DH occurrence was recorded with an average of 3.9 years before OCTA evaluation, and the most recent DH occurrence was an average of 1.9 years before the OCTA evaluation. Eyes with recent DH occurrence earlier than average (1.9 years) had mean (95% CI) wiCD loss of −0.77% (−1.14% to −0.39%) per year, while those later than average had −1.14% (−1.47% to −0.80%)
DISCUSSION
DHs have been identified as a risk factor for the development and progression of glaucoma.3, 4, 5, 6, 7, 8, 9, 10, 11 In this study, OCTA-derived measures of the rates of vessel density loss are significantly faster in DH eyes compared with non-DH eyes. Differences between the DH and non-DH groups were detected in the global rates of vessel density loss as well as in several sectoral rates of vessel density loss. While these findings support changes in optic disc microvasculature as being
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Supplemental Material available at AJO.com.
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Drs Moghimi and Nishida served jointly as first authors.