Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

Title:Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

Volume: 21 Issue: 14

Author(s): Kong Zhang, Tianze Li, Xijie Shan, Rongfei Lu, Shaoyong Zhang and Hui Xu*

Affiliation:

• College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province,China

Keywords: Cholesterol derivatives, biological activities, structural modification, mechanisms of action, structure-activity relationships.

Abstract: Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.

Cite this article as:

Zhang Kong , Li Tianze , Shan Xijie , Lu Rongfei, Zhang Shaoyong and Xu Hui *, Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships, Mini-Reviews in Medicinal Chemistry 2021; 21 (14) . https://dx.doi.org/10.2174/1389557521666210105123320