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Evaluation and comparison of the effects of biosynthesized selenium and silver nanoparticles using plant extracts with antifungal drugs on the growth of Aspergillus and Candida species

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Rendiconti Lincei. Scienze Fisiche e Naturali Aims and scope Submit manuscript

Abstract

The biosynthesis of nanoparticles stands as an uncomplicated, biocompatible, inexpensive, and secure approach for replacing the available chemical and physical methods. In this paper, Selenium nanoparticles (Se-NPs) and silver nanoparticles (Ag-NPs) were biosynthesized using Nepeta and Berberine plant extracts, respectively. UV–Vis, FT-IR, and FESEM/EDAX techniques were applied for confirming the synthesis of nanoparticles. In addition, the method of Minimum Inhibitory Concentration (MIC) was utilized to perform a sensitivity test on fungal species' leachates through the usage of Duplicate. The application biosynthesized Se-NPs and Ag-NPs at concentrations of 1 µg/mL and below caused no growth of fungal agents. However, antifungal drugs at concentrations higher than 1 µg/mL and even up to 64 µg/mL inhibited the growth of these drug-resistant fungi. A comparison of the results showed that even these nanoparticles in some cases have a better effect than the group of antifungal drugs. Therefore, the usage of biosynthesized nanoparticles is considered to be more convenient and economical due to the increasing drug resistance of opportunistic and pathogenic microorganisms towards the exerted target drugs.

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Acknowledgements

This project is based on the approved research plan No. 981697 of Mashhad University of Medical Sciences and we thank all the contributors of this research project.

Funding

This study was financed by the Mashhad University of Medical Sciences and we thank all the contributors of this research project (plan No. 981697).

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Author notes

  1. Mahdi Hosseini Bafghi and Hadi Safdari contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Microbiology, Faculty of Science, Qom Branch, Islamic Azad University, Qom, Iran

    Mahdi Hosseini Bafghi, Razieh Nazari & Mohsen Zargar

  2. Department of Laboratory Sciences, Faculty of Paramedical, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahdi Hosseini Bafghi & Hadi Safdari

  3. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

  4. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, School of Medicine, Mashhad, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

  5. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Sabouri

  6. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Zarrinfar

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  1. Mahdi Hosseini Bafghi
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Contributions

MHB: writing original draft, data acquisition, analysis, and interpretation. HS: data acquisition and interpretation. RN: data acquisition and interpretation. MD: supervision, project administration, review and editing, funding, and resources acquisition. ZS: data acquisition, analysis, and interpretation MZ: data acquisition and interpretation. HZ: supervision, project administration, review and editing, funding, and resources acquisition.

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Correspondence to Majid Darroudi or Hossein Zarrinfar.

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Hosseini Bafghi, M., Safdari, H., Nazari, R. et al. Evaluation and comparison of the effects of biosynthesized selenium and silver nanoparticles using plant extracts with antifungal drugs on the growth of Aspergillus and Candida species. Rend. Fis. Acc. Lincei 32, 791–803 (2021). https://doi.org/10.1007/s12210-021-01021-0

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