A novel redox cycle diverts cells from oncogene-induced senescence into cancer

doi:10.1016/j.molcel.2021.08.023

Molecular Cell

Volume 81, Issue 18, 16 September 2021, Pages 3672-3674

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Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTC^off) or malignant transformation (HTC^on).

Molecular Cell

PreviewA novel redox cycle diverts cells from oncogene-induced senescence into cancer

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A novel redox cycle diverts cells from oncogene-induced senescence into cancer