Abstract
This study elucidates the biosynthesis of two various metal nanoparticles using brown seaweed algae from the southeast coast region of Tamil Nadu. The synthesized SiO2–ZnO nanocomposite was analyzed using UV–Vis, SEM, FT-IR and XRD analysis. The biomedical studies of synthesized SiO2–ZnO nanocomposite on antioxidant, antibacterial and anticancer activity were evaluated. Antioxidant screening assays were performed by using nitric oxide, hydrogen peroxide and ABTS assay. MTT assay and well-cut drug diffusion assay were performed for anticancer and antibacterial studies. The bio-synthesized SiO2–ZnO nanocomposites have acted as a promising potential drug against HT29 cancer cell line of colon cancer and explore the best range of zone inhibition upon gram-negative and gram-positive bacterial strains. The results provide the facts that the seaweed mediated synthesis of SiO2–ZnO nanocomposite might be the potential source to treat adenorectal colon cancer cell and exhibits significant effect on Escherichia coli, Vibrio cholera, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. This study confirms that seaweed extract mediated synthesis of SiO2–ZnO nanocomposites significantly inhibits bacterial colonies especially urinary tract infection pathogens and shows excellent antioxidant activity.
Graphic Abstract
Schematic representation of synthesized SiO2–ZnO nanocomposites and their therapeutic evaluation.
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Bharathi, D.S., Boopathyraja, A., Nachimuthu, S. et al. Green Synthesis, Characterization and Antibacterial Activity of SiO2–ZnO Nanocomposite by Dictyota bartayresiana Extract and Its Cytotoxic Effect on HT29 Cell Line. J Clust Sci 33, 2499–2515 (2022). https://doi.org/10.1007/s10876-021-02170-w
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DOI: https://doi.org/10.1007/s10876-021-02170-w