Abstract
The effects of polyphenolic impurities on the biological activity of fucoidan samples from the brown alga Fucus distichus subsp. evanescens were studied using the model of developing embryos of the sea urchin Strongylocentrotus intermedius. The embryotoxic action of fucophloretol from F. evanescens (IC50 = 96.90 ± 12.20 μmol/L) and cucumarioside A7 (a triterpene glycoside) from Cucumaria frondosa subsp. japonica (IC50 = 0.39 ± 0.01 μmol/L) was assessed. The ability of fucoidans with different levels of polyphenolic impurities to partially or completely reduce the embryotoxic action of cucumarioside A7 from C. japonica has been shown.
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ACKNOWLEDGMENTS
We are grateful to A.V. Skriptsova, Cand. Sci. Biol., from the Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, for the identification of brown algae.
Funding
The study was financially supported by the Russian Foundation for Basic Research (project no. 20-04-00591).
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Kiseleva, M.I., Imbs, T.I., Avilov, S.A. et al. The Effects of Polyphenolic Impurities in Fucoidan Samples from the Brown Alga Fucus distichus subsp. evanescens (C. Agardh) H.T. Powell, 1957 on the Embryogenesis in the Sea Urchin Strongylocentrotus intermedius (A. Agassiz, 1864) and on the Embryotoxic Action of Cucumarioside. Russ J Mar Biol 47, 290–299 (2021). https://doi.org/10.1134/S1063074021040076
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DOI: https://doi.org/10.1134/S1063074021040076