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Temporal changes and prognostic value of plasma ghrelin level in patients with acute heart failure: a prospective study

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Abstract

Background

Plasma ghrelin levels can be elevated in patients with acute heart failure (AHF). This study aimed to analyze the temporal changes and prognostic value of ghrelin levels in patients with AHF.

Methods

This prospective study included patients with AHF at the Cardiology Department, Weifang People’s Hospital (May 2018–October 2019), and age- and sex-matched healthy controls. Plasma ghrelin levels were measured. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate whether ghrelin levels could predict major cardiac adverse events (MACEs) during a 1-year follow-up.

Results

Finally, 92 patients with AHF and 50 healthy controls were enrolled. Ghrelin levels were higher in patients with AHF at 1, 3, 12, and 24 h compared with controls (all P < 0.01). Ghrelin levels in the AHF group were higher at 3 and 12 h than at 1 and 24 h (P < 0.001). Ghrelin level at 3 h in patients with AHF was negatively correlated with the left ventricular end-diastolic diameter and left ventricular ejection fraction (both P < 0.05). MACEs occurred in 48 patients with AHF. Ghrelin levels were higher in the MACE group than in the non-MACE group at 1 (P = 0.011) and 3 h (P = 0.034). Multivariable regression showed that ghrelin level at 3 h was independently associated with MACEs [OR = 0.629, 95% confidence interval (CI): 0.515–0.742, P = 0.010], but the area under the ROC curve was only 0.629 (95% CI 0.515–0.742).

Conclusions

Plasma ghrelin levels are elevated in AHF and patients with MACEs during follow-up.

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Authors and Affiliations

  1. Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China

    Yanbo Chen & Lianqun Cui

  2. Department of Cardioangiology, Weifang People’s Hospital, Weifang, 261041, Shandong, China

    Yanbo Chen, Aiyuan Zhang, Jing Huang & Guangfang Zhang

  3. Central Sterile Supply Department, Weifang People’s Hospital, Weifang, 261041, Shandong, China

    Sani Zhou

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  1. Yanbo Chen
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Correspondence to Lianqun Cui.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Weifang People’s Hospital.

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Chen, Y., Zhou, S., Zhang, A. et al. Temporal changes and prognostic value of plasma ghrelin level in patients with acute heart failure: a prospective study. Heart Vessels 37, 419–425 (2022). https://doi.org/10.1007/s00380-021-01935-7

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  • DOI: https://doi.org/10.1007/s00380-021-01935-7

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