Abstract
The precise associations between dysphagia and palatal tremor (PT) remain unknown. We aimed to identify the association between PT and dysphagia among patients with midbrain/pontine stroke, compare the characteristics of dysphagia between patients with PT (PT + dysphagia) and without PT (PT− dysphagia), and verify neuroanatomical predictors of PT + dysphagia in this patient population. This retrospective observational study enrolled 40 patients (34 males, 6 females; mean age: 95% confidence interval [CI], 56.6 ± 14.6 years) with first-ever midbrain or pontine stroke exhibiting brain stem lesions admitted to the stroke unit of a single rehabilitation hospital between January 2010 and April 2020. Main outcome measures included dysphagia and aspiration rates and videofluoroscopic swallowing study findings. Lesion localization was stratified according to established vascular territories. Associations between PT and dysphagia and lesion location according to PT and dysphagia were analyzed. Dysphagia and aspiration rates were greater among patients with PT than among those without PT (95% CI, p = 0.030 and p = 0.017, respectively). The proportion of patients exhibiting oral stage impairment (95% CI, p = 0.007) was greater in the PT + dysphagia group than in the PT− dysphagia group. The posterolateral portion of the midbrain and pons (95% CI, p = 0.001 and p < 0.001, respectively) were the lesions more often involved in the PT + dysphagia group. Patients with PT following midbrain/pontine stroke more frequently present with dysphagia than those without PT. Thus, they should be carefully examined for PT and delayed dysphagia, including oral stage impairment, if initial brain images show posterolateral midbrain and pons lesions.
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
Joon-Ho Shin was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea.
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Joon-Ho Shin was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2018S1A5A2A03034582).
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J-HS and SL conceived and designed the study. SL analyzed the data. HIM analyzed the lesion data. J-HS and SL contributed to data interpretation. SL wrote the manuscript. J-HS critically revised the manuscript, and all the authors approved the final version of the manuscript.
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The Ethics Committee of the Institutional Review Board of the National Rehabilitation Center in South Korea approved this study (approval number: NRC-2020-01-006) and waived the requirement for informed consent due to its retrospective design.
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Lee, S., Moon, H.I. & Shin, JH. Post-stroke palatal tremor as a clinical predictor of dysphagia and its neuroanatomical correlates in patients with midbrain and pontine lesions. J Neural Transm 128, 1863–1872 (2021). https://doi.org/10.1007/s00702-021-02417-w
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DOI: https://doi.org/10.1007/s00702-021-02417-w