Synthesis of N-CF3 hydrazines through radical trifluoromethylation of azodicarboxylates†
Abstract
We report here the synthesis of a novel family of N-CF3 hydrazines from a direct way involving the available and cheap Langlois reagent (CF3SO2Na). These derivatives have shown very high stability whatever the conditions used and are excellent precursors for building previously inaccessible N-CF3 functionalized compounds, such as substituted hydrazides, hydrazine-amino-acids, hydrazones, N-aziridines and pyrazoles.
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