Two different simple, accurate, and precise UV spectrophotometric methods have been developed for the estimation of erlotinib hydrochloride in bulk and tablet forms by the zero-order (method I) and the zero-order AUC (method II). The drug was dissolved in a phosphate buffer solution (pH 7.4), and at 228.20 nm the zero-order (method I) and at 224.20–230.20 nm the zero-order AUC (method II) were developed. For both methods, erlotinib has linearity in the concentration range 10–70 μg/mL, with a correlation coefficient R2 > 0.99. Both methods showed good reproducibility and recovery with %RSD less than 2 and an accuracy of 98.54–101.39 and 98.08–99.83%, respectively. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.16, 3.51, and 21.41, 64.90 μg/mL, respectively, for both methods.
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Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 88, No. 4, p. 667, July–August, 2021.
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Rathod, R.D., Rathod, L.D., Mundada, A.B. et al. Validated UV Spectrophotometric Methods for the Determination of Anticancer Drug Erlotinib Hydrochloride in Bulk and Tablet Formulations. J Appl Spectrosc 88, 882–886 (2021). https://doi.org/10.1007/s10812-021-01254-9
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DOI: https://doi.org/10.1007/s10812-021-01254-9