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RETRACTED ARTICLE: Long noncoding RNA LINC00968 inhibits proliferation, migration and invasion of lung adenocarcinoma through targeting miR-22-5p/CDC14A axis

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This article was retracted on 05 April 2023

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Abstract

Lung adenocarcinoma (LUAD) is a high aggressive human cancer which usually diagnosed at advanced stages. Accumulating evidences indicate that long noncoding RNAs (lncRNAs) are crucial participants in LUAD progression. In the present study, we found that lncRNA LINC00968 was significantly down-regulated in LUAD tissues and cell lines. LINC00968 level was positively correlated to survival rate, and negatively correlated to tumor node metastasis (TNM) stage, tumor size and lymph node metastasis of LUAD patients. We over-expressed LINC00968 in LUAD cells using lentivirus, inhibited proliferation and cell cycle arrest at G1 phase were detected. LINC00968 over-expression also suppressed migration, invasion and epithelial mesenchymal transition. We further validated that LINC00968 localized in cytoplasm and acted as an upstream regulator of microRNA miR-22-5p, which was up-regulated in LUAD tissues and cell lines. Besides, elevated miR-22-5p expression abolished the effect of LINC00968 over-expression on LUAD progression including in vivo tumor growth. In addition, we first validated that cell division cycle 14A (CDC14A), which was down-regulated in LUAD tissues, was a downstream target of miR-22-5p. We over-expressed CDC14A in LUAD cells and miR-22-5p induced LUAD progression was partially reversed. In conclusion, our study demonstrated that LINC00968 inhibited proliferation, migration and invasion of LUAD by sponging miR-22-5p and further restoring CDC14A. This novel regulatory axis might provide us with promising diagnostic and therapeutic target in LUAD treatment.

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All data generated or analyzed during this study are included in this published article.

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Funding

This study was funded by Youth Project (2020QN009) of Xi’an International Medical Center Hospital.

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Author notes

  1. Chao Wu, Xuzhao Bian and Liyuan Zhang have contributed equally to this work.

Authors and Affiliations

  1. Department of Medical Quality Management, Xi’an International Medical Center Hospital, Xi’an, 710100, Shaanxi, People’s Republic of China

    Chao Wu, Xuzhao Bian, Yang Wu & Tianli Pei

  2. Department of Respiratory Medicine of Thoracic Hospital, Xi’an International Medical Center Hospital, No.777 Xitai Road, Gaoxin District, Xi’an, 710100, Shaanxi, People’s Republic of China

    Liyuan Zhang & XinPeng Han

  3. Medical College, Xijing University, Xi’an, 710100, Shaanxi, People’s Republic of China

    Yuanyuan Hu

Authors
  1. Chao Wu
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Correspondence to XinPeng Han.

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The authors declare that no competing interests exist.

Ethical approval

All experiment regarding clinical samples were performed in accordance with the ethical guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Xi’an International Medical Center Hospital.

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Written informed consent for publication was obtained from all participants.

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Clinical samples were collected with the consent of participants.

Additional information

This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s13205-023-03531-0

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Wu, C., Bian, X., Zhang, L. et al. RETRACTED ARTICLE: Long noncoding RNA LINC00968 inhibits proliferation, migration and invasion of lung adenocarcinoma through targeting miR-22-5p/CDC14A axis. 3 Biotech 11, 433 (2021). https://doi.org/10.1007/s13205-021-02981-8

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  • DOI: https://doi.org/10.1007/s13205-021-02981-8

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