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Recent Advances in Lactic Acid Production by Lactic Acid Bacteria

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Abstract

Lactic acid can synthesize high value-added chemicals such as poly lactic acid. In order to further minimize the cost of lactic acid production, some effective strategies (e.g., effective mutagenesis and metabolic engineering) have been applied to increase productive capacity of lactic acid bacteria. In addition, low-cost cheap raw materials (e.g., cheap carbon source and cheap nitrogen source) are also used to reduce the cost of lactic acid production. In this review, we summarized the recent developments in lactic acid production, including efficient strain modification technology (high-efficiency mutagenesis means, adaptive laboratory evolution, and metabolic engineering), the use of low-cost cheap raw materials, and also discussed the future prospects of this field, which could promote the development of lactic acid industry.

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Acknowledgements

The study was supported financially by the Major Program of the Inner Mongolia Autonomous Region of China (No. 2019ZD021), the National Natural Science Foundation of China Large Science Installation Joint Fund Cultivation Project (No. U1932141), and the National Natural Science Foundation of China Large Science Installation Fund Project (No. U2032210).

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  1. Department of Biophysics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China

    Xuejiao Tian, Hao Chen, Hao Liu & Jihong Chen

  2. University of Chinese Academy of Sciences, Beijing, People’s Republic of China

    Xuejiao Tian & Jihong Chen

  3. Gansu Agricultural University, 509 Nanchang Road, Lanzhou, 730000, China

    Hao Chen & Hao Liu

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XT: methodology, investigation, writing—original draft. HC: formal analysis, data curation. HL: visualization, resources. JC: funding support, resources, data curation, methodology, writing—review and editing.

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Correspondence to Jihong Chen.

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Tian, X., Chen, H., Liu, H. et al. Recent Advances in Lactic Acid Production by Lactic Acid Bacteria. Appl Biochem Biotechnol 193, 4151–4171 (2021). https://doi.org/10.1007/s12010-021-03672-z

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