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Salt substitution reduces the rate of cardiovascular events and death

Nature Reviews Cardiology volume 18, pages 738–739 (2021)Cite this article

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Substituting regular table salt (100% sodium chloride) with an alternative containing 25% potassium chloride reduces the rate of stroke, major cardiovascular events and all-cause death. This finding from the SSaSS trial was presented at the ESC Congress 2021.

After follow-up (mean 4.74 years), the rates of stroke (rate ratio (RR) 0.86), major cardiovascular events (RR 0.87) and all-cause death (RR 0.88) were all significantly reduced with the salt substitute compared with the regular salt. Of note, the rate of serious adverse events attributed to hyperkalaemia was not significantly different between the two groups (RR 1.04).

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  • He, F. J. & MacGregor, G. A. Role of salt intake in prevention of cardiovascular disease: controversies and challenges. Nat. Rev. Cardiol. 15, 371–377 (2018)

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Gregory B. Lim

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  1. Gregory B. Lim
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Correspondence to Gregory B. Lim.

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Lim, G.B. Salt substitution reduces the rate of cardiovascular events and death. Nat Rev Cardiol 18, 738–739 (2021). https://doi.org/10.1038/s41569-021-00615-3

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  • DOI: https://doi.org/10.1038/s41569-021-00615-3

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