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Radioiodinated Azilsartan as a New Highly Selective Radiotracer for Myocardial Perfusion Imaging

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Radiochemistry Aims and scope

Abstract

Azilsartan (AZ) was labeled with 131I using Chloramine-T as oxidizing agent. Factors affecting the labeling efficiency were systematically studied, and optimum conditions were found: oxidizing agent amount 100 μg, substrate amount 100 μg, pH 6, reaction time 30 min, and ambient temperature. Biodistribution studies showed that [131I]iodoAZ is concentrated in heart at 5 min post-injection to give high uptake of 29.0 ± 0.6% injected dose/g organ. Thus, iodoAZ shows promise as a radiotracer for heart imaging.

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ACKNOWLEDGMENTS

This work was supported by STDF – National Research Centre under project number 41535 – PI Ahmed Sayed Morsy Fouzy.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, PB13759, Cairo, Egypt

    M. H. Sanad & F. A. Marzook

  2. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China

    S. F. A. Rizvi

  3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 12578, Giza, Egypt

    A. B. Farag

  4. Food Toxicology and Contaminants Department, National Research Centre, Dokki, 12622, Cairo, Egypt

    A. S. M. Fouzy

Authors
  1. M. H. Sanad
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  2. F. A. Marzook
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  3. S. F. A. Rizvi
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  5. A. S. M. Fouzy
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Correspondence to S. F. A. Rizvi.

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Sanad, M.H., Marzook, F.A., Rizvi, S.F.A. et al. Radioiodinated Azilsartan as a New Highly Selective Radiotracer for Myocardial Perfusion Imaging. Radiochemistry 63, 520–525 (2021). https://doi.org/10.1134/S1066362221040160

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  • DOI: https://doi.org/10.1134/S1066362221040160

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