Dinuclear gold(I) complexes with N-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity

Gianmarco Trevisan; Valentina Vitali; Cristina Tubaro; Claudia Graiff; Anatoliy Marchenko; Georgyi Koidan; Anastasiia N. Hurieva; Aleksandr Kostyuk; Matteo Mauceri; Flavio Rizzolio; Gianluca Accorsi; Andrea Biffis

doi:10.1039/D1DT02444B

Dinuclear gold(i) complexes with N-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity†

Gianmarco Trevisan,^ab Valentina Vitali,^ab Cristina Tubaro,

^ab Claudia Graiff,

^c Anatoliy Marchenko,^d Georgyi Koidan,^d Anastasiia N. Hurieva,^d Aleksandr Kostyuk,^d Matteo Mauceri,^e Flavio Rizzolio,

^ef Gianluca Accorsi^g and Andrea Biffis

*^ab

Author affiliations

* Corresponding authors

^a Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, 35131 Padova, Italy
E-mail: andrea.biffis@unipd.it

^b CIRCC−Consorzio Interuniversitario per le Reattività Chimiche e la Catalisi, Università di Padova, via Marzolo 1, 35131 Padova, Italy

^c Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy

^d Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, Kyiv-94, Ukraine

^e Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Campus Scientifico Via Torino 155, 30174 Venezia-Mestre, Italy

^f Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano 33081, Italy

^g CNR NANOTEC, Institute of Nanotechnology, c/o Campus Ecotekne, via Monteroni, Lecce, Italy

Abstract

A small library of dinuclear gold(I) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting a rigid metallamacrocyclic structure can exhibit rather strong emissions that extend towards the red region of the visible spectrum. The in vitro anticancer activity of the complexes has been also preliminarly evaluated; cytotoxicity seems to correlate with complex lipophilicity, whereas selectivity towards cancer cells can be apparently enhanced upon a judicious choice of the ligands.

Dalton Transactions

Dinuclear gold(i) complexes with N-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity†

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